GPR37

G protein-spregnuti receptor 37
G protein-spregnuti receptor 37
Identifikatori
Simboli	GPR37; EDNRBL; PAELR; hET(B)R-LP
Vanjski ID	OMIM: 602583 MGI: 1313297 HomoloGene: 3875 IUPHAR: GPR37 GeneCards: GPR37 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora; • receptorska aktivnost; • aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	2861
Ensembl	ENSG00000170775
UniProt	O15354
RefSeq (mRNA)	NM_005302
RefSeq (protein)	NP_005293
Lokacija (UCSC)	Chr 7:; 124.17 - 124.19 Mb
PubMed pretraga	[1]

GPR37, G protein-spregnuti receptor 37, je protein koji je kod čoveka kodiran GPR37 genom.^[1]^[2]

Interakcije

Za GPR37 je pokazano da interaguje sa HSPA1A^[3] i parkin ligazom.^[3]^[4]

Reference

^ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (novembar 1997). „Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library”. Genomics. 45 (1): 68—77. PMID 9339362. doi:10.1006/geno.1997.4900.
^ „Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)”.
^ ^а ^б Imai, Yuzuru; Soda Mariko; et al. (jul 2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity”. Mol. Cell. United States. 10 (1): 55—67. ISSN 1097-2765. PMID 12150907. doi:10.1016/S1097-2765(02)00583-X.
^ Imai, Y; Soda M; et al. (jun 2001). „An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin”. Cell. United States. 105 (7): 891—902. ISSN 0092-8674. PMID 11439185. doi:10.1016/S0092-8674(01)00407-X.

Literatura

Zeng Z, Su K, Kyaw H, Li Y (1997). „A novel endothelin receptor type-B-like gene enriched in the brain.”. Biochem. Biophys. Res. Commun. 233 (2): 559—67. PMID 9144577. doi:10.1006/bbrc.1997.6408.
Donohue PJ; Shapira H; Mantey SA; et al. (1998). „A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system.”. Brain Res. Mol. Brain Res. 54 (1): 152—60. PMID 9526070. doi:10.1016/S0169-328X(97)00336-7.
Imai Y; Soda M; Inoue H; et al. (2001). „An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.”. Cell. 105 (7): 891—902. PMID 11439185. doi:10.1016/S0092-8674(01)00407-X.
Imai Y; Soda M; Hatakeyama S; et al. (2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.”. Mol. Cell. 10 (1): 55—67. PMID 12150907. doi:10.1016/S1097-2765(02)00583-X.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Yang Y; Nishimura I; Imai Y; et al. (2003). „Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.”. Neuron. 37 (6): 911—24. PMID 12670421. doi:10.1016/S0896-6273(03)00143-0.
Scherer SW; Cheung J; MacDonald JR; et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science. 300 (5620): 767—72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
Hillier LW; Fulton RS; Fulton LA; et al. (2003). „The DNA sequence of human chromosome 7.”. Nature. 424 (6945): 157—64. PMID 12853948. doi:10.1038/nature01782.
Imai Y; Soda M; Murakami T; et al. (2004). „A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.”. J. Biol. Chem. 278 (51): 51901—10. PMID 14532270. doi:10.1074/jbc.M309655200.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Kubota K; Niinuma Y; Kaneko M; et al. (2006). „Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.”. J. Neurochem. 97 (5): 1259—68. PMID 16539653. doi:10.1111/j.1471-4159.2006.03782.x.
Omura T; Kaneko M; Okuma Y; et al. (2007). „A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.”. J. Neurochem. 99 (6): 1456—69. PMID 17059562. doi:10.1111/j.1471-4159.2006.04155.x.

[pmid9339362-1] Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (novembar 1997). „Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library”. Genomics. 45 (1): 68—77. PMID 9339362. doi:10.1006/geno.1997.4900.

[entrez-2] „Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)”.

[pmid12150907-3] а ^б Imai, Yuzuru; Soda Mariko; et al. (jul 2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity”. Mol. Cell. United States. 10 (1): 55—67. ISSN 1097-2765. PMID 12150907. doi:10.1016/S1097-2765(02)00583-X.

[pmid11439185-4] Imai, Y; Soda M; et al. (jun 2001). „An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin”. Cell. United States. 105 (7): 891—902. ISSN 0092-8674. PMID 11439185. doi:10.1016/S0092-8674(01)00407-X.

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