Galaninski receptor 2
Galaninski receptor 2, (GAL2) je G protein spregnuti receptor kodiran GALR2 genom.[1]
| Galaninski receptor 2 | |||
|---|---|---|---|
| Identifikatori | |||
| Simboli | GALR2; GALNR2; MGC125983; MGC125984 | ||
| Vanjski ID | OMIM: 603691 MGI: 1337018 HomoloGene: 2863 IUPHAR: GAL2 GeneCards: GALR2 Gene | ||
| Pregled RNK izražavanja | |||
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| podaci | |||
| Ortolozi | |||
| Vrsta | Čovek | Miš | |
| Entrez | 8811 | 14428 | |
| Ensembl | ENSG00000182687 | ENSMUSG00000020793 | |
| UniProt | O43603 | Q14A53 | |
| RefSeq (mRNA) | NM_003857 | NM_010254 | |
| RefSeq (protein) | NP_003848 | NP_034384 | |
| Lokacija (UCSC) |
Chr 17: 71.58 - 71.59 Mb |
Chr 11: 116.1 - 116.1 Mb | |
| PubMed pretraga | [1] | [2] | |
Galanin je važan neuromodulator prisutan u mozgu, gastrointestinalnom sistemu, i hipotalamo-hipofiznoj osi. To je peptid sa 30 aminokiselina koji nije C-terminalno amidiran. On potentno stimuliše sekreciju hormona rasta, usporava brzinu srca, ukida sinusnu aritmiju, i inhibira gastrointestinalni motilitet nakon obroka. Dejstvo galanina je posredovano kroz interakciju sa specifičnim membranskim receptorima koji su članovi 7-transmembranske familije G protein-spregnutih receptora. GALR2 interaguje sa N-terminalnim ostacima galanina. Primarni signalni mehanizam GALR2 receptora je put fosfolipaze C/protein kinaze C (preko Gq), u kontrastu sa GALR1, koji prenosi svoj signal inhibicijom adenilat ciklaze kroz Gi. Bilo je pokazano da se GALR2 efektivno spreže sa Gq i Gi proteinima, i da može da simultano aktivira dva nezavisna puta prenosa signala.[1]
Vidi još
уредиLiteratura
уредиDodatna literatura
уреди- Bloomquist BT; Beauchamp MR; Zhelnin L; et al. (1998). „Cloning and expression of the human galanin receptor GalR2.”. Biochem. Biophys. Res. Commun. 243 (2): 474—9. PMID 9480833. doi:10.1006/bbrc.1998.8133.
- Fathi Z; Battaglino PM; Iben LG; et al. (1998). „Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.”. Brain Res. Mol. Brain Res. 58 (1-2): 156—69. PMID 9685625. doi:10.1016/S0169-328X(98)00116-8.
- Kolakowski LF; O'Neill GP; Howard AD; et al. (1998). „Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.”. J. Neurochem. 71 (6): 2239—51. PMID 9832121. doi:10.1046/j.1471-4159.1998.71062239.x.
- Borowsky B; Walker MW; Huang LY; et al. (1999). „Cloning and characterization of the human galanin GALR2 receptor.”. Peptides. 19 (10): 1771—81. PMID 9880084. doi:10.1016/S0196-9781(98)00133-8.
- Berger A; Tuechler C; Almer D; et al. (2002). „Elevated expression of galanin receptors in childhood neuroblastic tumors.”. Neuroendocrinology. 75 (2): 130—8. PMID 11867941. doi:10.1159/000048229.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Berger A; Lang R; Moritz K; et al. (2004). „Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cells.”. Endocrinology. 145 (2): 500—7. PMID 14592962. doi:10.1210/en.2003-0649.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Belfer I; Hipp H; Bollettino A; et al. (2007). „Alcoholism is associated with GALR3 but not two other galanin receptor genes.”. Genes, Brain and Behavior. 6 (5): 473—81. PMID 17083333. doi:10.1111/j.1601-183X.2006.00275.x.
Spoljašnje veze
уреди- „Galanin Receptors: GAL2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.