Prazikvantel

Prazikvantel
Klinički podaci
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	0,8-1,5 h
Identifikatori
CAS broj	55268-74-1
ATC kod	P02BA01 (WHO)
PubChem	CID 4891
DrugBank	DB01058
ChemSpider	4722
KEGG	C07367
ChEMBL	CHEMBL976
Hemijski podaci
Formula	C19H24N2O2
Molarna masa	312,406
	SMILES O=C(C1CCCCC1)N1CC2N(CCC3=CC=CC=C23)C(=O)C1; ;
	InChI InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2 ; Key:FSVJFNAIGNNGKK-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	136 °C (277 °F)

Prazikvantel je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 312,406 Da.^[1]^[2]^[3]^[4]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	0
Broj rotacionih veza	1
Particioni koeficijent^[5] (ALogP)	2,5
Rastvorljivost^[6] (logS, log(mol/L))	-3,1
Polarna površina^[7] (PSA, Å²)	40,6

Reference

^ Doenhoff, M. J.; Cioli, D.; Utzinger, J. (децембар 2008). „Praziquantel: Mechanisms of action, resistance and new derivatives for schistosomiasis”. Current Opinion in Infectious Diseases. 21 (6): 659—67. PMID 18978535. doi:10.1097/QCO.0b013e328318978f.
^ McManus, D. P.; Loukas, A. (јануар 2008). „Current status of vaccines for schistosomiasis”. Clinical Microbiology Reviews. 21 (1): 225—42. PMC 2223839  . PMID 18202444. doi:10.1128/CMR.00046-07.
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709  . PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889  . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Praziquantel

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Doenhoff, M. J.; Cioli, D.; Utzinger, J. (децембар 2008). „Praziquantel: Mechanisms of action, resistance and new derivatives for schistosomiasis”. Current Opinion in Infectious Diseases. 21 (6): 659—67. PMID 18978535. doi:10.1097/QCO.0b013e328318978f.

[2] McManus, D. P.; Loukas, A. (јануар 2008). „Current status of vaccines for schistosomiasis”. Clinical Microbiology Reviews. 21 (1): 225—42. PMC 2223839  . PMID 18202444. doi:10.1128/CMR.00046-07.

[3] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709  . PMID 21059682. doi:10.1093/nar/gkq1126.

[4] David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889  . PMID 18048412. doi:10.1093/nar/gkm958.

[5] Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.

[6] Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[7] Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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