Metaciklin
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(IUPAC) ime | |||
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(4S,4aR,5S,5aR,12aS)-4-(dimetilamino)-5,10,12,12a-tetrahidroksi-6-metiliden-1,3,11-triokso-1,2,3,4,4a,5,5a,6,11,12a-dekahidrotetracen-2-karboksamid | |||
Klinički podaci | |||
AHFS/Drugs.com | Monografija | ||
Identifikatori | |||
CAS broj | 914-00-1 | ||
ATC kod | J01AA05 | ||
DrugBank | DB00931 | ||
KEGG[1] | C07654 ![]() | ||
Hemijski podaci | |||
Formula | C22H22N2O8 | ||
Mol. masa | 442,4187 | ||
SMILES | eMolekuli & PubHem | ||
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Farmakokinetički podaci | |||
Poluvreme eliminacije | 14 sata | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Metaciklin je semisintetički antibiotik širokog spektra dejstva koji je srodan sa tetraciklinima. On se izlučuje sporije od tetraciklina i održava efektivne nivoe u krvi tokom dužeg perioda.[2][3][4][5]
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Agwuh KN, MacGowan A: Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. 2006 Aug;58(2):256-65. Epub 2006 Jul 1. PMID 16816396
- ↑ Li J, Chen L, Wang X, Jin H, Ding L, Zhang K, Zhang H: Determination of tetracyclines residues in honey by on-line solid-phase extraction high-performance liquid chromatography. Talanta. 2008 Jun 15;75(5):1245-52. Epub 2008 Jan 20. PMID 18585209
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
- ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.