Koagulacioni faktor Xa
| Koagulacioni faktor Xa | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.21.6 | ||||||||
| CAS broj | 2594078 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Koagulacioni faktor Xa (EC 3.4.21.6, trombokinaza, protrombaza, protrombinaza, aktivirani krvno-koagulacioni faktor X, autoprotrombinska C, tromboplastin, plazmični tromboplastin, faktor Xa, aktivirani Stjuart-Prauer faktor, aktivirani faktor X) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Selektivno razlaganje Arg-Thr i zatim Arg-Ile veza u protrombinu čime se formira trombin
Ovaj krvno koagulacioni faktor se formira iz proenzima faktor X putem ograničene proteolize.
- ↑ Fujikawa, K. and Davie, E.W. (1976). „Bovine factor X (Stuart factor)”. Methods Enzymol. 45: 89-95. PMID 1012041.
- ↑ Jesty, J. and Nemerson, Y. (1976). „The activation of bovine coagulation factor X”. Methods Enzymol. 45: 95-107. PMID 1012042.
- ↑ Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. (1979). „The role of serine proteases in the blood coagulation cascade”. Adv. Enzymol. 48: 277-318. PMID 367103.
- ↑ Jackson, C.M. and Nemerson, Y. (1980). „Blood coagulation”. Annu. Rev. Biochem. 49: 765-811. PMID 6996572.
- ↑ McMullen, B.A., Fujikawa, K., Kisiel, W., Sasagawa, T., Howald, W.N., Kwa, E.Y. and Weinstein, B. (1983). „Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as β-hydroxyaspartic acid”. Biochemistry 22: 2875-2884. PMID 6871167.
- ↑ Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry 23: 644-650. PMID 6370301.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.