Citrulin

Citrulin
	2-Amino-5-(karbamoilamino)pentanoinska kiselina
Identifikacija
CAS registarski broj	627-77-0 , 13594-51-9 R , 372-75-8 S
PubChem	833, ; 637599 R, ; 9750 S
ChemSpider	810 , 553200 R , 9367 S
UNII	29VT07BGDA
EINECS broj	211-012-2
DrugBank	DB00155
KEGG	D07706
MeSH	Citrulline
ChEBI	18211
ChEMBL	CHEMBL444814
IUPHAR ligand	722
Bajlštajn	1725417, 1725415 R, 1725416 S
Gmelin Referenca	774677 S
3DMet	B01217
Jmol-3D slike	Slika 1; Slika 2
SMILES
	NC(CCC[nH]:c(:[nH2]):[o])c(:[o]):[oH] NC(CCCNC(N)=O)C(O)=O
InChI
	InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12) ; Kod: RHGKLRLOHDJJDR-UHFFFAOYSA-N
Svojstva
Molekulska formula	C6H13N3O3
Molarna masa	175.19 g mol−1
Agregatno stanje	Beli kristali
Miris	Bez mirisa
log P	−1,373
pKa	2,508
Baznost (pKb)	11,489
Termohemija
Standardna molarna entropija So298	254,4 J K−1 mol−1
Specifični toplotni kapacitet, C	232,80 J K−1 mol−1
Srodna jedinjenja
Srodna alkanoinske kiseline	N-Acetilaspartinska kiselina; Aceglutamid; N-Acetilglutaminska kiselina; Pivagabin;
Srodna jedinjenja	Bromizoval; Karbromal;
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Organsko jedinjenje citrulin je α-aminokiselina. Ime jedinjenja potiče od lat. citrullus za lubenica, iz koje je prvi put izolovano 1914. Finalna identifikacija je urađena 1930.^[7] Njegova hemijska formula je H₂NC(O)NH(CH₂)₃CH(NH₂)CO₂H. On je ključni intermedijer u ciklusu ureje, metaboličkom putu kojim životinje izlučuju amonijak.

Reference

↑ „Citrulline - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 16. 9. 2004.. Identification. Pristupljeno 1. 5. 2012.
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Fearon, William Robert (1939). „The Carbamido Diacetyl Reaction: A Test For Citrulline”. Biochemical Journal 33 (6): 902–907.

Povezano

Citrulinemija

Vanjske veze

Portal Hemija

[1] „Citrulline - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 16. 9. 2004.. Identification. Pristupljeno 1. 5. 2012.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[5] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[6] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[7] Fearon, William Robert (1939). „The Carbamido Diacetyl Reaction: A Test For Citrulline”. Biochemical Journal 33 (6): 902–907.

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