Arahidonat 5-lipoksigenaza

Arachidonat 5-lipoksigenaza
Identifikatori
EC broj	1.13.11.34
CAS broj	80619-02-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Arahidonat 5-lipoksigenaza (EC 1.13.11.34, leukotrien-A4 sintaza, Delta5-lipoksigenaza, 5Delta-lipoksigenaza, arahidonska 5-lipoksigenaza, arahidonska kiselina 5-lipoksigenaza, C-5-lipoksigenaza, LTA sintaza, leukotrienska A4 sintaza) je enzim sa sistematskim imenom arachidonat:kiseonik 5-oksidoreduktaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

arahidonat + O₂

\rightleftharpoons

leukotrien A4 + H₂O (sveukupna reakcija)

(1a) arahidonat + O₂

\rightleftharpoons

(6E,8Z,11Z,14Z)-(5S)-5-hidroperoksiikosa-6,8,11,14-tetraenoat

(1b) (6E,8Z,11Z,14Z)-(5S)-5-hidroperoksiikosa-6,8,11,14-tetraenoat

\rightleftharpoons

leukotrien A4 +H₂O

Reference

↑ Matsumoto, T., Funk, C.D., Radmark, O., Hoog, J.-O., Jornvall, H. and Samuelsson, B. (1988). „Molecular cloning and amino acid sequence of human 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA 85: 26-30. PMID 2829172.
↑ Ohishi, N., Izumi, T., Minami, M., Kitamura, S., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F. and Shimizu, T. (1987). „Leukotriene A₄ hydrolase in the human lung. Inactivation of the enzyme with leukotriene A₄ isomers”. J. Biol. Chem. 262: 10200-10205. PMID 3038871.
↑ Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., Rädmark, O. and Samuelsson, B. (1986). „Characterization of leukotriene A₄ synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA 83: 4175-4179. PMID 3012557.
↑ Shimizu, T., Rädmark, O. and Samuelssohn, B. (1984). „Enzyme with dual lipoxygenase activities catalyzes leukotriene A₄ synthesis from arachidonic acid”. Proc. Natl. Acad. Sci. USA 81: 689-693. PMID 6322165.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Arachidonate+5-lipoxygenase

[1] Matsumoto, T., Funk, C.D., Radmark, O., Hoog, J.-O., Jornvall, H. and Samuelsson, B. (1988). „Molecular cloning and amino acid sequence of human 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA 85: 26-30. PMID 2829172.

[2] Ohishi, N., Izumi, T., Minami, M., Kitamura, S., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F. and Shimizu, T. (1987). „Leukotriene A₄ hydrolase in the human lung. Inactivation of the enzyme with leukotriene A₄ isomers”. J. Biol. Chem. 262: 10200-10205. PMID 3038871.

[3] Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., Rädmark, O. and Samuelsson, B. (1986). „Characterization of leukotriene A₄ synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase”. Proc. Natl. Acad. Sci. USA 83: 4175-4179. PMID 3012557.

[4] Shimizu, T., Rädmark, O. and Samuelssohn, B. (1984). „Enzyme with dual lipoxygenase activities catalyzes leukotriene A₄ synthesis from arachidonic acid”. Proc. Natl. Acad. Sci. USA 81: 689-693. PMID 6322165.

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[2]

[3]

[4]

p r u Proteini: enzimi
Teme	Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6