UR-AK49

UR-AK49
(IUPAC) ime
	3-cikloheksil-N-[(3-1H-imidazol-4-ilpropilamino)(imino)metil]propanamid
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
ChemSpider	21486130
ChEMBL	CHEMBL486974
Hemijski podaci
Formula	C16H27N5O
Mol. masa	305,417 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C16H27N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,18,20)(H3,17,19,21,22) ; Key: QBGKYFYOFBXHFM-UHFFFAOYSA-N
Sinonimi	UR-AK49
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

UR-AK49 je lek koji se koristi u naučnim istraživanjima, i koji deluje kao potentan antagonist za neuropeptid Y / pankreasnom polipeptidnom receptoru Y₄, i koji je takođe parcijalni agonist histaminskih receptora H₁ i H₂.^[3] UR-AK49 je čist antagonist na Y₄ bez parcijalnog agonistnog dejstva, i mada je samo neznatno selektivniji za Y₄ u odnosu na srodne Y₁ i Y₅ receptore, kao prvi ne-peptidni Y₄ antagonist očekuje se da će UR-AK49 biti koristan u ispitivanjima tog receptora i njegove uloge u telu.^[4]

Literatura

↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Xie SX, Kraus A, Ghorai P, Ye QZ, Elz S, Buschauer A, Seifert R (June 2006). „N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)propylguanidine (UR-AK57), a potent partial agonist for the human histamine H1- and H2-receptors”]. The Journal of Pharmacology and Experimental Therapeutics 317 (3): 1262–8. DOI:10.1124/jpet.106.102897. PMID 16554355.
↑ Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). „Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence”. Journal of Receptor and Signal Transduction Research 27 (4): 217–33. DOI:10.1080/10799890701505206. PMID 17885919.

Vanjske veze

	Portal Medicina
	Portal Hemija

Šablon:Neuropeptidni ligandi

[1] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[2] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid16554355-3] Xie SX, Kraus A, Ghorai P, Ye QZ, Elz S, Buschauer A, Seifert R (June 2006). „N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)propylguanidine (UR-AK57), a potent partial agonist for the human histamine H1- and H2-receptors”]. The Journal of Pharmacology and Experimental Therapeutics 317 (3): 1262–8. DOI:10.1124/jpet.106.102897. PMID 16554355.

[pmid17885919-4] Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). „Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence”. Journal of Receptor and Signal Transduction Research 27 (4): 217–33. DOI:10.1080/10799890701505206. PMID 17885919.

[3]

[4]

[1]

[2]