We are thrilled to announce that Klaus Langhoff-Roos has been appointed as our new Chief Executive Officer. Klaus joins to bring his expertise in the stem cell field and leadership track record to support BioLamina through a period of accelerated scale-up and growth. He brings over 15 years of experience leading international teams through successful life science scale-up and commercialization journeys. Learn more about him and his ambitions for BioLamina in our press release ➡ https://lnkd.in/dQF26T3v #BioLamina #Leadership #Biotechnology #LifeSciences #CEO #Growth
BioLamina
Forskning inom bioteknik
Cell-specific culture matrices for improved cell functionality
Om oss
BioLamina is a Swedish biotechnology company with a global presence, offering cell culture matrices for primary cells. We offer an expansive portfolio of recombinant laminin proteins for a variety of applications, including the reliable expansion of pluripotent cell and differentiation and maintenance of specialized cell types. Our chemically defined and xeno-free laminin cell culture matrices allow you to imitate the natural cell-matrix interaction in vitro. Laminins are key components of the extracellular matrix. Through their interactions with specific receptors, laminins trigger the authentic cellular responses, pivotal for cell anchorage, survival, proliferation, migration, organization, and specialization, leading to improved cell functionality. BioLamina’s laminins are the only original full length, human, recombinant laminins on the market. Our high technology products contribute to our customer’s efficiency and scientific breakthroughs and enable them to start a new era in medical research. We are known and recognized for our premium products, competence, dedication, and service and position ourselves as being in the forefront of cell culturing. Our vision is to make BioLamina a leading brand within the field of cell culture and to help make cell therapy a reality. BioLamina is built on a scientific foundation with a legacy in matrix biology and solid experience in cell culture-based research. The company was started in 2009 and was co-founded by Dr. Karl Tryggvason and his son Dr. Kristian Tryggvason. Today the company has about 35 employees spanning from production, R&D, logistics, sales, and marketing. Our quality system complies with ISO 9001:2015 and both management and employees follow well-defined standard processes and agreements.
- Webbplats
-
http://www.biolamina.com
Extern länk för BioLamina
- Bransch
- Forskning inom bioteknik
- Företagsstorlek
- 51–200 anställda
- Huvudkontor
- Sundbyberg
- Typ
- Privatägt företag
- Grundat
- 2009
- Specialistområden
- Cell culture, Stem cell culture and differentiation och Laminin
Adresser
-
Primär
Löfströms Allé 5
Sundbyberg, 17266, SE
-
One Broadway
Cambridge, MA 02142 , US
Anställda på BioLamina
Uppdateringar
-
Full-length laminin = Full function. A recent review by Drs. Yurchenco and Kulczyk highlights the critical role of intact laminins in maintaining healthy tissues. Only full-length laminin is able to polymerize, bind to all cell receptors, and interact with extracellular factors. In cell culture, only the full-length laminin substrate can truly mimic the versatile interactions between cells and laminin, naturally enhancing cell survival and identity. Fragments simply lack the essential protein regions needed for these interactions to occur. Check out the review to learn all about polymerizing laminins in the body: https://lnkd.in/daHrNDEs #MolecularBiology #TissueEngineering #BiomedicalResearch PS. Discover more about full-length laminins in cell culture in our application note: https://lnkd.in/dqy2CZCr
-
-
Ever wonder how our brain controls hunger? With a data-driven approach and learnings from model organisms, scientists cleverly fine-tuned their human neuronal differentiation protocol to create specific neurons in the hypothalamus that manage our appetite. The timing of BMP addition was crucial for deriving these specific cell lineages that were differentiated on Biolaminin 111. Access to in vitro cell models like this enables detailed investigation of responses to hormones, drug candidates, as well as CRISPR-screens for obesity research. #Neurons #Hypothalamus #Appetite #CellModels
Appetite-regulating neurons in the dish? Sounded like an outlandish research project to me 5 years ago, but now I'm excited to share our new preprint on exactly this topic. The focus is on the hypothalamus. Hormones like Leptin and #GLP1 as well as new blockbuster weight-lowering drugs #Ozempic, #Wegovy and #Zepbound have been shown to act on hypothalamic circuits through which they affect activity of key appetite-regulating neurons POMC and AGRP. These neurons are located in the arcuate nucleus which is just one of the more than 10 tiny subregions of the #hypothalamus, but the exact molecular and cellular pathways involved in human hypothalamic appetite regulation are still not clear. Therefore, access to human models of appetite-regulating neurons for investigation of drug and hormone responses would be highly valuable. In this new preprint from our group, we show that we have cracked the code for generating highly specific and pure cultures of human Arcuate Nucleus neurons and tanycytes from stem cells in the dish, and we found that these cultures respond to the appetite-regulating hormone leptin. The underlying secret for differentiation turned out to be a tightly controlled temporal activation of BMP signalling: Only if you add and withdraw BMP at exactly the right time will the cells develop into Arcuate Nucleus neurons and tanycytes. We also showed that by tweaking the time-window for BMP signalling further, we were able to control the generation of the neighbouring ventromedial (VMH) hypothalamic region which is also involved in appetite regulation. A key take-home message from our study is that the generation of POMC neurons in itself surprisingly does not indicate correct patterning towards the Arcuate Nucleus, as it seems POMC neurons can also arise from a multitude of different non-ARC neural progenitors. This work was done by our amazing Team Hypothalamus at the Novo Nordisk Foundation Center for Stem Cell Medicine – reNEW: Zehra Abay - Nørgaard, Anika Mueller and Erno Hänninen together with Louise Piilgaard, Jens Bager Christensen, Sofie Peeters, Alrik Schörling, Alison Salvador, Yuan Li, Viktoriia Nikulina, Janko Kajtez and our close collaborators Dylan Rausch and Tune Pers. If you're curious to learn more, then check out our preprint here: https://lnkd.in/dw-Znp8v
-
-
Did you know our full-length, human recombinant laminins have been shown to effectively combine with both natural and synthetic 3D matrices? The biofunctionalization of these hydrogels with our Biolaminin® substrates has been proven to improve cell survival, attachment, and differentiation of PSC-derived cells into eye, liver and cardiac cells, amongst other cell types. Enhanced cell type-specific responses, such as better barrier formation and metabolic activity have also been reported. Tissue-specific functionalization of multiple hydrogel types for improved tissue modelling, now made possible with Biolaminin! Read our latest application note here to learn more -> https://t.ly/keqB1 #Biolaminin #3DModels #TissueEngineering #BiomedicalResearch #Innovation #Drugdiscovery #Drugdevelopment
-
-
Organ-on-Chip (OoC) devices are replacing animal models in drug development - but non-biological materials often limit their physiological relevance and performance. To replace non-degradable synthetic polymers commonly used to separate fluidic channels, Xingrui Mou and colleagues developed a Biolaminin-functionalized silk fibroin membrane, demonstrating its effectiveness in a human kidney chip in their recent study. Notably, the Biolaminin-functionalized membrane is: ➡ Biological: Enables functional remodeling of ECM and transmembrane cell communication. ➡ Ultrathin: Thinner than traditional PDMS, closely resembling the in vivo basement membrane. ➡ Consistent: Maintains molecular and conformational composition across batches. With desirable high porosity and mechanical properties similar to the in vivo tissue, this fibroin membrane could become the new standard in OoC devices. Read the full study, Mou et al. 2024 Science Advances: 📰 https://lnkd.in/dqnQqgWe PS. Are you thinking of adding crucial biological cues to your material? Contact us! #OrganOnChip #TissueEngineering
-
Stem cells are picky. A recent study reveals that laminin-511 isoform is not produced at all in the human embryonic stem cell niche. 511 would never completely fill their stringent criteria. Instead, full-length laminin-521 ticks all the boxes. It is even the first basement membrane protein to appear during development, making it absolutely crucial for stem cell survival and stability. In nature, laminin proteins are always full-length and intact. Otherwise, they can’t function. Similarly, Biolaminin® proteins are always full-length. PS. Did you know that we are, in fact, the sole provider of full-length laminins? Discover the benefits of full-length laminin-521 in stem cell culture: https://lnkd.in/dMfDzmuq Got insights? Share with us! -------- See the full study about BM development during human embryogenesis, Rosner et al. 2024 Developmental Cell: https://lnkd.in/dGb-zUdj #StemCells #StemCellCulture #PSC #Laminin
-
-
Some cherry-picking done yesterday from Dr. Karl Tryggvason's, our scientific founder, cherry tree (with permission, we promise! 😉) All these delicious fruits are now ready for some molecular cooking. We will follow recipes / protocols to get the best results. Cherry-picking in science? No, thank you! With consistently performing cell culture, you don’t need to exclude replicates and cherry-pick data. See this example of how the chemically defined, biologically relevant Biolaminin substrate offers reproducibility in cardiomyocyte differentiation ➡ https://lnkd.in/dDZMmNfw #NoMoreCherryPicking #ScientificIntegrity #Biolaminin #cardiomyocyte #cellculture
-
-
Thank you for meeting us at #ISSCR2024 in Hamburg last week. We were thrilled to celebrate with you our 15th anniversary, but also take you through our poster presentations, and welcome you to our innovation showcase. We loved to learn more about your research and discuss how our full-length Biolaminin® matrices can support your cell culture. Do you have a question about our Biolaminin® matrices? Contact us now ➡ https://lnkd.in/d8YvhRha See you next year in Hong Kong, International Society for Stem Cell Research!
-
-
It is really thrilling to hear about the most significant new advances in the stem cell research and regenerative medicine fields at #ISSCR2024! On this third day, don't miss the following poster presentations: 📌 From 3:45 to 4:45, Susanne Gröndahl from BioLamina will present poster #363 “Full-length laminins are crucial for recreating the cellular niche in vitro“ 📌 From 4:45 to 5:45, Dr. Malin Kele (Eriksson) will talk about how “Recombinant laminin proteins provide a biologically relevant niche for primary cells in vitro, mimicking the natural niche for both adult stem cells and cancer cells” in her poster #408 📌From 4:45 to 5:45, Dr. Diana Chaker from INSERM, will present her poster #338 : "Generation and characterization of clinical grade human master cell banks of induced pluripotent stem cells (iPSC) with high expansion potential." Come and see how our Biolaminin® 521 Clinical Therapy Grade (CTG) and Biolaminin 521 MX were used in her scalable protocol. Bis bald! Want to learn more about our full-length laminins? Come to our booth #903 until 6:00.
-
Last day of exhibition at #ISSCR2024 and last chance to visit us at booth 903. We would love to hear more about you and your research. Susanne Gröndahl , Dr. Therese Kallur , Dr. Malin Kele (Eriksson), Evan L. Graham, PhD and Camille Fournier-Sandberg
-