In this article, we introduce a class of multilinear fractional integral operators with generalized kernels that are weaker than the Dini kernel condition. We establish the boundedness of multilinear fractional integral operators with generalized kernels on weighted Lebesgue spaces and variable exponent Lebesgue spaces, as well as the boundedness of multilinear commutators generated by multilinear fractional integral operators with generalized kernels and $BMO$ functions. Even when the generalized kernels condition goes back to the Dini kernel condition, the conclusions on the commutators remain new.