Drug‐induced liver injury (DILI) is the most frequent reason cited for the withdrawal of
approved drugs from the market and accounts for up to 15% of the cases of acute liver …

Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …

CYP3A4 present in small bowel enterocytes can catalyze substantial metabolism of some
orally administered drugs and, thus, exerts a first-pass effect. Recent data indicate that the P …

Objective.—To characterize the hepatic effects of tacrine treatment in patients with
Alzheimer's disease. Design.—Controlled trials of tacrine therapy consisting of two blinded …

Family studies show that the Huntington's disease gene is linked to a polymorphic DNA
marker that maps to human chromosome 4. The chromosomal localization of the …

Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating
steroid levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is …

The amyloid β protein has been identified as an important component of both
cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome …

ContextDuring a clinical trial of a novel hydrocodone/acetaminophen combination, a high
incidence of serum alanine aminotransferase (ALT) elevations was observed. ObjectiveTo …

Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. Several
families have been described in which Alzheimer's disease is caused by an autosomal …

Ob/ob mice, a model for nonalcoholic fatty liver disease (NAFLD), develop intestinal
bacterial overgrowth and overexpress tumor necrosis factor α (TNF-α). In animal models for …