Drug-metabolizing enzymes (DMEs) and transporters play pivotal roles in the disposition
and detoxification of numerous foreign and endogenous chemicals. To accommodate …

During the past several years, important advances have been made in our understanding of
the mechanisms that regulate the expression of genes that determine drug clearance …

Human CYP2B6 has been thought to account for a minor portion (< 1%) of total hepatic
cytochrome P450 (CYP) content and to have a minor function in human drug metabolism …

Type-A receptors for the neurotransmitter GABA (γ-aminobutyric acid) are ligand-gated
chloride channels that mediate inhibitory neurotransmission. Each subunit of the pentameric …

The mitogen-activated protein kinase (MAPK) and cyclic adenosine monophosphate (cAMP)
signal transduction pathways have critical roles in the consolidation of hippocampus …

Both the human pregnane X receptor (hPXR) and constitutive androstane receptor (hCAR)
are capable of regulating CYP3A4 and CYP2B6 gene expression. However, the majority of …

Importance Patients with metastatic colorectal cancer (CRC) have limited effective and
tolerable treatment options. Objective To evaluate the efficacy and safety of oral fruquintinib …

Cyclic AMP is a positive regulator of synaptic plasticity and is required for several forms of
hippocampus-dependent memory including recognition memory. The type I adenylyl …

Abstract Two-dimensional (2D) MXene Ti 3 C 2 nanosheets are prepared by liquid phase
exfoliation of layered Ti 3 AlC 2 in aqueous solution of HF, followed by alkalization and …

The objectives of this study were to evaluate the ability of 14 compounds, which differentially
activate human pregnane X receptor (hPXR), to induce CYP2B6 expression and to compare …