Doxycycline post exposure prophylaxis could select for cross-resistance to other antimicrobials in various pathogens: an in silico analysis

Z Gestels, SS Manoharan-Basil… - International journal of …, 2023 - journals.sagepub.com
Background A number of randomized controlled trials have found that doxycycline post
exposure prophylaxis (PEP) can reduce the incidence of gonorrhoea, chlamydia and syphilis in …

Could traces of fluoroquinolones in food induce ciprofloxacin resistance in Escherichia coli and Klebsiella pneumoniae? An in vivo study in Galleria mellonella with …

Z Gestels, Y Baranchyk, D Van den Bossche… - Microbiology …, 2024 - Am Soc Microbiol
This study found that the concentrations of ciprofloxacin/enrofloxacin allowed in food can
induce de novo ciprofloxacin resistance in Klebsiella pneumoniae . This suggests that it would …

Doxycycline PEP can induce doxycycline resistance in Klebsiella pneumoniae in a Galleria mellonella model of PEP

C Kenyon, Z Gestels, T Vanbaelen, S Abdellati… - Frontiers in …, 2023 - frontiersin.org
Background Four randomized controlled trials have now established that doxycycline post
exposure (sex) prophylaxis (PEP) can reduce the incidence of chlamydia and syphilis in men …

Microbisporicin (NAI-107) protects Galleria mellonella from infection with Neisseria gonorrhoeae

N Hofkens, Z Gestels, S Abdellati… - Microbiology …, 2023 - Am Soc Microbiol
Due to the increasing incidence of antibiotic-resistant bacterial pathogens, the need for the
development of alternative compounds is of utmost importance. Bacteriocins are considered …

Ciprofloxacin Concentrations 100-Fold Lower than the MIC Can Select for Ciprofloxacin Resistance in Neisseria subflava: An In Vitro Study

Z Gestels, S Abdellati, C Kenyon, SS Manoharan-Basil - Antibiotics, 2024 - mdpi.com
Neisseria gonorrhoeae can acquire antimicrobial resistance (AMR) through horizontal gene
transfer (HGT) from other Neisseria spp. such as commensals like Neisseria subflava. Low …

Ramoplanin as a novel therapy for Neisseria gonorrhoeae infection: an in vitro and in vivo study in Galleria mellonella

Z Gestels, I De Baetselier… - Journal of Medical …, 2024 - microbiologyresearch.org
Neisseria gonorrhoeae is a bacterial pathogen that causes gonorrhoea, a sexually transmitted
infection. Increasing antimicrobial resistance in N. gonorrhoeae is providing motivation to …

Genome Mining Uncovers NRPS and PKS Clusters in Rothia dentocariosa with Inhibitory Activity against Neisseria Species

EA Akomoneh, Z Gestels, S Abdellati, K Vereecken… - Antibiotics, 2023 - mdpi.com
The growing global threat of antimicrobial resistance is reaching a crisis point as common
bacterial infections, including those caused by pathogenic Neisseria species, are becoming …

Protective effect of microbisporicin (NAI-107) against vancomycin resistant Enterococcus faecium infection in a Galleria mellonella model

N Hofkens, Z Gestels, S Abdellati, P Gabant… - Scientific Reports, 2024 - nature.com
Increasing antimicrobial resistance in Enterococcus faecium necessitates the search for novel
treatment agents, such as bacteriocins. In this study, we conducted an in vivo assessment …

Evidence of horizontal gene transfer within porB in 19 018 whole-genome Neisseria spp. isolates: a global phylogenetic analysis

SS Manoharan-Basil, Z Gestels… - Microbial …, 2023 - microbiologyresearch.org
The PorB porins are the major pore-forming proteins in the genus Neisseria . The trimeric
PorB porins consist of 16 highly conserved transmembrane domains that form an amphipathic …

Antimicrobial susceptibility of commensal Neisseria spp. in parents and their children in Belgium: a cross-sectional survey

S Abdellati, Z Gestels, JGE Laumen… - FEMS Microbiology …, 2024 - academic.oup.com
Background: commensal Neisseria species are part of the oropharyngeal microbiome and
play an important role in nitrate reduction and protecting against colonization by pathogenic …