A global decrease in microRNA (miRNA) levels is often observed in human cancers 1 , 2 ,
indicating that small RNAs may have an intrinsic function in tumour suppression. To identify …

RNA interference (RNAi) is an evolutionarily conserved process through which double-stranded
RNA (dsRNA) induces the silencing of cognate genes (for review, see Bernstein et al. …

Increasingly powerful sequencing technologies are ushering in an era of personal genome
sequences and raising the possibility of using such information to guide medical decisions. …

A growing number of long nuclear‐retained non‐coding RNAs (ncRNAs) have recently been
described. However, few functions have been elucidated for these ncRNAs. Here, we have …

Epigenetic mechanisms have been proposed to play crucial roles in mammalian development,
but their precise functions are only partially understood. To investigate epigenetic …

Multiple mechanisms have evolved to regulate the eukaryotic genome. We have identified
CTN-RNA, a mouse tissue-specific ∼8 kb nuclear-retained poly(A) + RNA that regulates the …

Methods for the direct detection of copy number variation (CNV) genome-wide have become
effective instruments for identifying genetic risk factors for disease. The application of next-…

Dicer is an essential component of RNA interference (RNAi) pathways, which have broad
functions in gene regulation and genome organization. Probing the consequences of tissue-…

Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting
uncontrolled proliferation. In mammals, the role that polarity proteins play during …

Identifying the downstream targets of microRNAs (miRNAs) is essential to understanding
cellular regulatory networks. We devised a direct biochemical method for miRNA target …