B7 family proteins provide costimulatory signals that regulate T cell responses. Here we
report the third set of B7 family-related T cell inhibitory molecules with the identification of a …

B7-H3 and B7x are recently discovered members of the B7-CD28 family thought to dampen
peripheral immune responses via negative costimulation. We evaluated their potential …

During activation, T cells express receptors for receiving positive and negative costimulatory
signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin …

The programmed death 1 (PD-1) receptor and its ligands programmed death ligand 1 (PD-L1)
and PD-L2, members of the CD28 and B7 families, play critical roles in T cell coinhibition …

B7-H3 and B7x are members of the B7 family of immune regulatory ligands that are thought
to attenuate peripheral immune responses through co-inhibition. Previous studies have …

B7-H3 (CD276) is an important immune checkpoint member of the B7 and CD28 families.
Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition of T-cell …

The activation and development of an adaptive immune response is initiated by the engagement
of a T-cell antigen receptor by an antigenic peptide-MHC complex. The outcome of this …

Alternatively activated macrophages (AAMΦ) are found in abundance during chronic Th2
inflammatory responses to metazoan parasites. Important roles for these macrophages are …

Purpose: Cancer-associated fibroblasts (CAFs) are an important component of the tumor
microenvironment, but a systematic investigation of their molecular characteristics and clinical …

T-cell costimulation and coinhibition generated by engagement of the B7 family and their
receptor CD28 family are of central importance in regulating the T-cell response, making these …