User profiles for Xingxing Zang
![]() | Xingxing ZangProfessor and Louis Goldstein Swan Endowed Chair, Albert Einstein College of Medicine Verified email at einsteinmed.edu Cited by 11129 |
B7x: a widely expressed B7 family member that inhibits T cell activation
B7 family proteins provide costimulatory signals that regulate T cell responses. Here we
report the third set of B7 family-related T cell inhibitory molecules with the identification of a …
report the third set of B7 family-related T cell inhibitory molecules with the identification of a …
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
X Zang, RH Thompson… - Proceedings of the …, 2007 - National Acad Sciences
B7-H3 and B7x are recently discovered members of the B7-CD28 family thought to dampen
peripheral immune responses via negative costimulation. We evaluated their potential …
peripheral immune responses via negative costimulation. We evaluated their potential …
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
…, MA Hurchla, N Zimmerman, J Sim, X Zang… - Nature …, 2003 - nature.com
During activation, T cells express receptors for receiving positive and negative costimulatory
signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin …
signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin …
Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway
…, A Assal, E Lazar-Molnar, Y Yao, X Zang - Trends in molecular …, 2015 - cell.com
The programmed death 1 (PD-1) receptor and its ligands programmed death ligand 1 (PD-L1)
and PD-L2, members of the CD28 and B7 families, play critical roles in T cell coinhibition …
and PD-L2, members of the CD28 and B7 families, play critical roles in T cell coinhibition …
[HTML][HTML] Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas
B7-H3 and B7x are members of the B7 family of immune regulatory ligands that are thought
to attenuate peripheral immune responses through co-inhibition. Previous studies have …
to attenuate peripheral immune responses through co-inhibition. Previous studies have …
Molecular pathways: targeting B7-H3 (CD276) for human cancer immunotherapy
E Picarda, KC Ohaegbulam, X Zang - Clinical Cancer Research, 2016 - AACR
B7-H3 (CD276) is an important immune checkpoint member of the B7 and CD28 families.
Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition of T-cell …
Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition of T-cell …
The B7 family and cancer therapy: costimulation and coinhibition
X Zang, JP Allison - Clinical cancer research, 2007 - AACR
The activation and development of an adaptive immune response is initiated by the engagement
of a T-cell antigen receptor by an antigenic peptide-MHC complex. The outcome of this …
of a T-cell antigen receptor by an antigenic peptide-MHC complex. The outcome of this …
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection
Alternatively activated macrophages (AAMΦ) are found in abundance during chronic Th2
inflammatory responses to metazoan parasites. Important roles for these macrophages are …
inflammatory responses to metazoan parasites. Important roles for these macrophages are …
Molecular features of cancer-associated fibroblast subtypes and their implication on cancer pathogenesis, prognosis, and immunotherapy resistance
Purpose: Cancer-associated fibroblasts (CAFs) are an important component of the tumor
microenvironment, but a systematic investigation of their molecular characteristics and clinical …
microenvironment, but a systematic investigation of their molecular characteristics and clinical …
HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function
…, A Zhao, MD Scharff, X Zang - Proceedings of the …, 2013 - National Acad Sciences
T-cell costimulation and coinhibition generated by engagement of the B7 family and their
receptor CD28 family are of central importance in regulating the T-cell response, making these …
receptor CD28 family are of central importance in regulating the T-cell response, making these …