Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

Genome-wide association scans with high-throughput metabolic profiling provide unprecedented
insights into how genetic variation influences metabolism and complex disease. Here …

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

Sequence-based variation in gene expression is a key driver of disease risk. Common
variants regulating expression in cis have been mapped in many expression quantitative trait …

There is a growing realization that some aging-associated phenotypes/diseases have an
epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics during …

Age-related changes in DNA methylation have been implicated in cellular senescence and
longevity, yet the causes and functional consequences of these variants remain unclear. To …

While there have been studies exploring regulatory variation in one or more tissues, the
complexity of tissue-specificity in multiple primary tissues is not yet well understood. We explore …

Platelets are the second most abundant cell type in blood and are essential for maintaining
haemostasis. Their count and volume are tightly controlled within narrow physiological …

Epigenetic modifications such as DNA methylation play a key role in gene regulation and
disease susceptibility. However, little is known about the genome-wide frequency, localization, …