Intracellular accumulation of amyloid-Beta-a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease
Despite of long-standing evidence that beta-amyloid (Aβ) peptides have detrimental effects
on synaptic function, the relationship between Aβ, synaptic and neuron loss is largely unclear…
on synaptic function, the relationship between Aβ, synaptic and neuron loss is largely unclear…
Evidence for activation of microglia in patients with psychiatric illnesses
Activation of microglia/macrophages is a key event in response to pathological changes in
the CNS. HLA-DR is a valuable immunohistochemical marker that specifically reacts with …
the CNS. HLA-DR is a valuable immunohistochemical marker that specifically reacts with …
DNA: a programmable force sensor
…, S Hirler, T Mai, I Gilbert, S Schiffmann, T Bayer… - Science, 2003 - science.org
Direct quantification of biomolecular interaction by single-molecule force spectroscopy has
evolved into a powerful tool for materials and life sciences. We introduce an approach in …
evolved into a powerful tool for materials and life sciences. We introduce an approach in …
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice
TA Bayer, S Schäfer, A Simons… - Proceedings of the …, 2003 - National Acad Sciences
The Cu-binding β-amyloid precursor protein (APP), and the amyloid Aβ peptide have been
proposed to play a role in physiological metal regulation. There is accumulating evidence of …
proposed to play a role in physiological metal regulation. There is accumulating evidence of …
Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's …
S Jawhar, A Trawicka, C Jenneckens, TA Bayer… - Neurobiology of …, 2012 - Elsevier
In the present report, we extend previous findings in the 5XFAD mouse model and demonstrate
that these mice develop an age-dependent motor phenotype in addition to working …
that these mice develop an age-dependent motor phenotype in addition to working …
Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease
Pyroglutamate-modified amyloid-β (Aβ pE3 ) peptides are gaining considerable attention as
potential key participants in the pathology of Alzheimer disease (AD) due to their …
potential key participants in the pathology of Alzheimer disease (AD) due to their …
A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide–the first step of a fatal cascade
Accumulating evidence points to an important role of intraneuronal Aβ as a trigger of the
pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's …
pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's …
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Aβ42 accumulation in a novel Alzheimer transgenic model
…, J Benavides, C Schmitz, G Tremp, TA Bayer… - The American journal of …, 2004 - Elsevier
Alzheimer's disease (AD) is characterized by a substantial degeneration of pyramidal neurons
and the appearance of neuritic plaques and neurofibrillary tangles. Here we present a …
and the appearance of neuritic plaques and neurofibrillary tangles. Here we present a …
High temperature proton conduction in nanocellulose membranes: paper fuel cells
Polymer electrolyte membrane fuel cells are an efficient and clean alternative power source,
but high cost impedes widespread commercialization. The fuel cell membrane, eg, Nafion, …
but high cost impedes widespread commercialization. The fuel cell membrane, eg, Nafion, …
Recent trends in biocatalysis
D Yi, T Bayer, CPS Badenhorst, S Wu… - Chemical Society …, 2021 - pubs.rsc.org
… Thomas Bayer Thomas Bayer graduated in the Molecular Biology programme from the …
Thomas Bayer received the Erwin Schrödinger fellowship by The Austrian Science Fund (…
Thomas Bayer received the Erwin Schrödinger fellowship by The Austrian Science Fund (…