Despite of long-standing evidence that beta-amyloid (Aβ) peptides have detrimental effects
on synaptic function, the relationship between Aβ, synaptic and neuron loss is largely unclear…

Activation of microglia/macrophages is a key event in response to pathological changes in
the CNS. HLA-DR is a valuable immunohistochemical marker that specifically reacts with …

Direct quantification of biomolecular interaction by single-molecule force spectroscopy has
evolved into a powerful tool for materials and life sciences. We introduce an approach in …

The Cu-binding β-amyloid precursor protein (APP), and the amyloid Aβ peptide have been
proposed to play a role in physiological metal regulation. There is accumulating evidence of …

In the present report, we extend previous findings in the 5XFAD mouse model and demonstrate
that these mice develop an age-dependent motor phenotype in addition to working …

Pyroglutamate-modified amyloid-β (Aβ pE3 ) peptides are gaining considerable attention as
potential key participants in the pathology of Alzheimer disease (AD) due to their …

Accumulating evidence points to an important role of intraneuronal Aβ as a trigger of the
pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's …

Alzheimer's disease (AD) is characterized by a substantial degeneration of pyramidal neurons
and the appearance of neuritic plaques and neurofibrillary tangles. Here we present a …

Polymer electrolyte membrane fuel cells are an efficient and clean alternative power source,
but high cost impedes widespread commercialization. The fuel cell membrane, eg, Nafion, …

… Thomas Bayer Thomas Bayer graduated in the Molecular Biology programme from the …
Thomas Bayer received the Erwin Schrödinger fellowship by The Austrian Science Fund (…