Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study
…, RJ Bjork, G Blevins, M Boehringer, T Boerner… - The Lancet, 2018 - thelancet.com
Background No treatment has consistently shown efficacy in slowing disability progression
in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of …
in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of …
Genetic determinants of outcome in intrahepatic cholangiocarcinoma
Background and Aim Genetic alterations in intrahepatic cholangiocarcinoma (iCCA) are
increasingly well characterized, but their impact on outcome and prognosis remains unknown. …
increasingly well characterized, but their impact on outcome and prognosis remains unknown. …
The Cyanobacterial Hepatotoxin Microcystin Binds to Proteins and Increases the Fitness of Microcystis under Oxidative Stress Conditions
Microcystins are cyanobacterial toxins that represent a serious threat to drinking water and
recreational lakes worldwide. Here, we show that microcystin fulfils an important function …
recreational lakes worldwide. Here, we show that microcystin fulfils an important function …
Assessment of hepatic arterial infusion of floxuridine in combination with systemic gemcitabine and oxaliplatin in patients with unresectable intrahepatic …
Importance Unresectable intrahepatic cholangiocarcinoma (IHC) carries a poor prognosis,
with a median overall survival (OS) of 11 months. Hepatic arterial infusion (HAI) of high-dose …
with a median overall survival (OS) of 11 months. Hepatic arterial infusion (HAI) of high-dose …
Is hepatectomy justified for BRAF mutant colorectal liver metastases?: a multi-institutional analysis of 1497 patients
Objective: To analyze clinical outcomes and prognostic variables of patients undergoing
hepatic resection for BRAF mutant (BRAF-mut) colorectal liver metastases (CRLM). Background…
hepatic resection for BRAF mutant (BRAF-mut) colorectal liver metastases (CRLM). Background…
Long-term oncologic outcomes following robotic liver resections for primary hepatobiliary malignancies: a multicenter study
Objective Robotic liver surgery (RLS) has emerged as a feasible alternative to laparoscopic
or open resections with comparable perioperative outcomes. Little is known about the …
or open resections with comparable perioperative outcomes. Little is known about the …
Long-term and oncologic outcomes of robotic versus laparoscopic liver resection for metastatic colorectal cancer: a multicenter, propensity score matching analysis
Background To assess long-term oncologic outcomes of robotic-assisted liver resection (RLR)
for colorectal cancer (CRC) metastases as compared to a propensity-matched cohort of …
for colorectal cancer (CRC) metastases as compared to a propensity-matched cohort of …
Incidence and management of esophageal cancer recurrence to regional lymph nodes after curative esophagectomy
T Boerner, RA Carr, M Hsu, A Michel… - … journal of cancer, 2023 - Wiley Online Library
Up to 50% of patients treated with curative esophagectomy for esophageal cancer will
develop recurrence, contributing to the dismal survival associated with this disease. Regional …
develop recurrence, contributing to the dismal survival associated with this disease. Regional …
Robotic versus open minor liver resections of the posterosuperior segments: a multinational, propensity score-matched study
Background Minor liver resections of posterosuperior segments (1, 4A, 7, 8) are challenging
to perform laparoscopically and are mainly performed using an open approach. We …
to perform laparoscopically and are mainly performed using an open approach. We …
Intrahepatic cholangiocarcinomas have histologically and immunophenotypically distinct small and large duct patterns
Intrahepatic cholangiocarcinomas are histologically heterogenous. Using a cohort of 184
clinically defined, resected intrahepatic cholangiocarcinomas, we retrospectively classified the …
clinically defined, resected intrahepatic cholangiocarcinomas, we retrospectively classified the …