Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study
T Ishida, T Joh, N Uike, K Yamamoto… - Journal of Clinical …, 2012 - ascopubs.org
Purpose Adult T-cell leukemia-lymphoma (ATL) is usually resistant to conventional
chemotherapies, and there are few other treatment options. Because CC chemokine receptor 4 (…
chemotherapies, and there are few other treatment options. Because CC chemokine receptor 4 (…
PrDOS: prediction of disordered protein regions from amino acid sequence
T Ishida, K Kinoshita - Nucleic acids research, 2007 - academic.oup.com
PrDOS is a server that predicts the disordered regions of a protein from its amino acid sequence
( http://prdos.hgc.jp ). The server accepts a single protein amino acid sequence, in either …
( http://prdos.hgc.jp ). The server accepts a single protein amino acid sequence, in either …
Specific recruitment of CC chemokine receptor 4–positive regulatory T cells in Hodgkin lymphoma fosters immune privilege
T Ishida, T Ishii, A Inagaki, H Yano, H Komatsu, S Iida… - Cancer research, 2006 - AACR
Hodgkin lymphoma (HL) is characterized by the presence of a small number of tumor cells in
a rich background of inflammatory cells, but the contribution of the abundant nontumor cells …
a rich background of inflammatory cells, but the contribution of the abundant nontumor cells …
Prediction of disordered regions in proteins based on the meta approach
T Ishida, K Kinoshita - Bioinformatics, 2008 - academic.oup.com
Motivation: Intrinsically disordered regions in proteins have no unique stable structures
without their partner molecules, thus these regions sometimes prevent high-quality structure …
without their partner molecules, thus these regions sometimes prevent high-quality structure …
Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anti-cc chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma …
M Ogura, T Ishida, K Hatake, M Taniwaki… - Journal of Clinical …, 2014 - ascopubs.org
Purpose CC chemokine receptor 4 (CCR4) is expressed by peripheral T-cell lymphomas (PTCLs)
and is associated with poor outcomes. Mogamulizumab (KW-0761) is a defucosylated …
and is associated with poor outcomes. Mogamulizumab (KW-0761) is a defucosylated …
D2P2: database of disordered protein predictions
We present the Database of Disordered Protein Prediction (D 2 P 2 ), available at http://d2p2.pro
(including website source code). A battery of disorder predictors and their variants, VL-…
(including website source code). A battery of disorder predictors and their variants, VL-…
Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome
T Ishida, A Utsunomiya, S Iida, H Inagaki… - Clinical Cancer …, 2003 - AACR
Adult T-cell leukemia/lymphoma (ATLL) is a distinct clinical entity among mature T-cell
neoplasms, and its causative agent has been confirmed to be long-term infection by human T-…
neoplasms, and its causative agent has been confirmed to be long-term infection by human T-…
Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma
…, H Inagaki, K Ohshima, H Kiyoi, T Ishida… - Journal of Clinical …, 2010 - ascopubs.org
Purpose KW-0761, a defucosylated humanized anti-CC chemokine receptor 4 (CCR4)
antibody, exerts a strong antibody-dependent cellular cytotoxic effect. This phase I study …
antibody, exerts a strong antibody-dependent cellular cytotoxic effect. This phase I study …
Functional Analyses of LONELY GUY Cytokinin-Activating Enzymes Reveal the Importance of the Direct Activation Pathway in Arabidopsis
…, H Tokunaga, M Kojima, N Ueda, T Ishida… - The Plant …, 2009 - academic.oup.com
Cytokinins play crucial roles in diverse aspects of plant growth and development. Spatiotemporal
distribution of bioactive cytokinins is finely regulated by metabolic enzymes. LONELY …
distribution of bioactive cytokinins is finely regulated by metabolic enzymes. LONELY …
Dose‐intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T‐cell leukaemia‐lymphoma: a randomized phase …
T Ishida, T Jo, S Takemoto… - British journal of …, 2015 - Wiley Online Library
This multicentre, randomized, phase II study was conducted to examine whether the addition
of mogamulizumab, a humanized anti‐ CC chemokine receptor 4 antibody, to mLSG 15, a …
of mogamulizumab, a humanized anti‐ CC chemokine receptor 4 antibody, to mLSG 15, a …