The amyloid-β peptide Aβ42 is known to be a primary amyloidogenic and pathogenic agent
in Alzheimer's disease. However, the role of Aβ43, which is found just as frequently in the …

Alzheimer amyloid β-peptide (Aβ) is a physiological peptide constantly anabolized and
catabolized under normal conditions. We investigated the mechanism of catabolism by tracing …

We analyzed an amino-terminal modification of p-amy-Ioid (A~) peptide in brain, using anti-Al~
antibodies that distinguish distinct molecular species. Examination of cortical sections …

Amyloid β peptide (Aβ), the pathogenic agent of Alzheimer's disease (AD), is a
physiological metabolite in the brain. We examined the role of neprilysin, a candidate Aβ-degrading …

Calpain, calcium‐activated neutral protease, stands as a unique receptor for calcium signals
in biological systems; its activation leads to irreversible proteolytic processing of substrate …

Experimental studies of Alzheimer's disease have largely depended on transgenic mice
overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial …

Expression of somatostatin in the brain declines during aging in various mammals including
apes and humans 1 , 2 . A prominent decrease in this neuropeptide also represents a …

Formation of senile plaques composed of amyloid β peptide, a pathological hallmark of
Alzheimer disease, in human brains precedes disease onset by many years. Noninvasive …

Alzheimer's disease (AD) is a neurodegenerative disease biochemically characterized by
aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein …

We aimed to determine quantitatively the fine amino- and carboxyl-terminal structure of Aβ
peptides deposited in human brain using a set of 12 anti-Aβ antibodies that distinguish …