Tau in physiology and pathology
Y Wang, E Mandelkow - Nature reviews neuroscience, 2016 - nature.com
… based on the isoform composition of tau aggregates. The splicing of the gene encoding tau
is regulated by multiple factors besides tau mutations. Tau is a natively unfolded protein that …
is regulated by multiple factors besides tau mutations. Tau is a natively unfolded protein that …
Tau pathology and neurodegeneration
MG Spillantini, M Goedert - The Lancet Neurology, 2013 - thelancet.com
… to hyperphosphorylated, insoluble and filamentous tau protein is at the centre of many … tau,
cause forms of frontotemporal dementia and parkinsonism, proving that dysfunction of tau is …
cause forms of frontotemporal dementia and parkinsonism, proving that dysfunction of tau is …
The role of tau in neurodegeneration
TF Gendron, L Petrucelli - Molecular neurodegeneration, 2009 - Springer
… normal tau function. To truly appreciate the detrimental consequences of … tau function, a
better understanding of all functions carried out by tau, including but not limited to the role of tau …
better understanding of all functions carried out by tau, including but not limited to the role of tau …
Tau in Alzheimer disease and related tauopathies
… tau in AD brain is distinguished from transiently hyperphosphorylated tau by its ability (1) to
sequester normal tau… hyperphosphorylated tau, because of oligomerization, unlike normal tau…
sequester normal tau… hyperphosphorylated tau, because of oligomerization, unlike normal tau…
[HTML][HTML] Tau, tangles, and Alzheimer's disease
LI Binder, AL Guillozet-Bongaarts… - … et Biophysica Acta (BBA …, 2005 - Elsevier
… the tau molecule when it attained the Tau-66 state. Cleavage at the N-terminus could abolish
tau's … This would allow tau to attain the Tau-66 state. Studies using N-terminally modified …
tau's … This would allow tau to attain the Tau-66 state. Studies using N-terminally modified …
Mechanisms of tau-induced neurodegeneration
… The 2N4R tau is the largest size human brain tau with a total of 441 amino acids (tau 441 )
in length. The smallest size tau isoform (0N3R; tau 352 ) is the only form that is expressed in …
in length. The smallest size tau isoform (0N3R; tau 352 ) is the only form that is expressed in …
Tau imaging: early progress and future directions
VL Villemagne, MT Fodero-Tavoletti… - The Lancet …, 2015 - thelancet.com
… tau imaging will allow the in-vivo exploration of such associations and measure the global
and regional changes in tau … of tau deposition over time, providing insight into the role tau …
and regional changes in tau … of tau deposition over time, providing insight into the role tau …
[HTML][HTML] Tau pathology in Alzheimer disease and other tauopathies
… of tau. The abnormal hyperphosphorylation not only results in the loss of tau function of … a
toxic function whereby the pathological tau sequesters normal tau, MAP1A/MAP1B and MAP2, …
toxic function whereby the pathological tau sequesters normal tau, MAP1A/MAP1B and MAP2, …
Tau in Alzheimer's disease
EM Mandelkow, E Mandelkow - Trends in cell biology, 1998 - cell.com
… in the gene encoding tau. This article discusses how changes in tau protein could lead to
retraction of neuronal processes and thus cell death and argues that tau pathology, rather than …
retraction of neuronal processes and thus cell death and argues that tau pathology, rather than …
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
AC Alonso, I Grundke-Iqbal, K Iqbal - Nature medicine, 1996 - nature.com
… AD P-tau works as nucleation centers to which the normal tau aggregates, forming … tau
inhibits its association with normal tau and the formation of the tangles. Furthermore, the AD P-tau …
inhibits its association with normal tau and the formation of the tangles. Furthermore, the AD P-tau …