… based on the isoform composition of tau aggregates. The splicing of the gene encoding tau
is regulated by multiple factors besides tau mutations. Tau is a natively unfolded protein that …

… to hyperphosphorylated, insoluble and filamentous tau protein is at the centre of many … tau,
cause forms of frontotemporal dementia and parkinsonism, proving that dysfunction of tau is …

… normal tau function. To truly appreciate the detrimental consequences of … tau function, a
better understanding of all functions carried out by tau, including but not limited to the role of tau …

… tau in AD brain is distinguished from transiently hyperphosphorylated tau by its ability (1) to
sequester normal tau… hyperphosphorylated tau, because of oligomerization, unlike normal tau…

… the tau molecule when it attained the Tau-66 state. Cleavage at the N-terminus could abolish
tau's … This would allow tau to attain the Tau-66 state. Studies using N-terminally modified …

… The 2N4R tau is the largest size human brain tau with a total of 441 amino acids (tau 441 )
in length. The smallest size tau isoform (0N3R; tau 352 ) is the only form that is expressed in …

… tau imaging will allow the in-vivo exploration of such associations and measure the global
and regional changes in tau … of tau deposition over time, providing insight into the role tau …

… of tau. The abnormal hyperphosphorylation not only results in the loss of tau function of … a
toxic function whereby the pathological tau sequesters normal tau, MAP1A/MAP1B and MAP2, …

… in the gene encoding tau. This article discusses how changes in tau protein could lead to
retraction of neuronal processes and thus cell death and argues that tau pathology, rather than …

… AD P-tau works as nucleation centers to which the normal tau aggregates, forming … tau
inhibits its association with normal tau and the formation of the tangles. Furthermore, the AD P-tau …