Several studies report varying incidence rates of cancer in subsites of the colorectum, as an
increasing proportion appears to develop in the proximal colon. Varying incidence trends
together with biological differences between the colorectal segments raise questions of
whether lifestyle factors impact on the risk of cancer differently at colorectal subsites. We
provide an updated overview of the risk of cancer at different colorectal subsites (proximal
colon, distal colon, and rectum) according to BMI and physical activity to shed light on this …

Objective. A shift in the total incidence from left‐to right‐sided colon cancer has been
reported and raises the question as to whether lifestyle risk factors are responsible for the
changing subsite distribution of colon cancer. The present study provides a review of the
subsite‐specific risk estimates for the dietary components presently regarded as convincing
or probable risk factors for colorectal cancer: red meat, processed meat, fiber, garlic, milk,
calcium, and alcohol. Methods. Studies were identified by searching PubMed through …