Macrophages play a key role in both normal and pathological processes involving immune
and inflammatory responses, to a large extent through their capacity to secrete a wide range …

Nanoparticles of gold, which are in the size range 10–100nm, undergo a plasmon resonance
with light. This is a process whereby the electrons of the gold resonate in response to …

Ion channels are known to be present on the plasma membrane of virtually all cells and have
been found on the membranes of various intracellular organelles. However, until recently …

The increasing number of bacterial strains that are resistant to available pharmaceutical
compounds is a vital issue for public health. Innovative approaches will be required to improve …

Objectives Gold nanoparticles (AuNPs) of 21 nm have been previously well characterized in
vitro for their capacity to target macrophages via active uptake. However, the short-term …

CLIC1 (NCC27) is a member of the highly conserved class of chloride ion channels that exists
in both soluble and integral membrane forms. Purified CLIC1 can integrate into synthetic …

Establishing and maintaining mature bone at the bone–device interface is critical to the long-term
success of prosthesis. Poor cell adhesion to orthopaedic and dental implants results in …

Chloride intracellular channel proteins (CLICs) are distinct from most ion channels in that they
have both soluble and integral membrane forms. CLICs are highly conserved in chordates…

NCC27 is a nuclear chloride ion channel, identified in the PMA-activated U937 human
monocyte cell line. NCC27 mRNA is expressed in virtually all cells and tissues and the gene …

Conjugates of gold nanoparticles and antibodies have useful functionalities. Here, we show
how they can be used to selectively target and destroy parasitic protozoans. Gold nanorods …