Brain metastases (BrMs) are a common occurrence in lung cancer with a dismal outcome.
To understand the mechanism of metastasis to inform prognosis and treatment, here we …

The polycomb repressive complex 2 (PRC2) is the major methyltransferase for H3K27
methylation, a modification critical for maintaining repressed gene expression programs …

Lysine methylation occurs on both histone and nonhistone proteins. However, our knowledge
on the prevalence and function of nonhistone protein methylation is poor. We describe an …

The SH3 domain, which normally recognizes proline-rich sequences, has the potential to bind
motifs with an RxxK consensus. To explore this novel specificity, we have determined the …

The X-linked lymphoproliferative (XLP) syndrome gene encodes a protein named SAP or
SH2D1A that is composed of a single Src homology 2 (SH2) domain. Two models have been …

Cellular functions require specific protein-protein interactions that are often mediated by
modular domains that use binding pockets to engage particular sequence motifs in their partners…

The human proteome contains a plethora of short linear motifs (SLiMs) that serve as binding
interfaces for modular protein domains. Such interactions are crucial for signaling and other …

Epithelial‐mesenchymal transition (EMT), which can be caused by aberrant tyrosine kinase
signalling, marks epithelial tumour progression and metastasis, yet the underlying molecular …

Although Numb exhibits its tumor-suppressive function in breast cancer in part by binding to
and stabilizing p53, it is unknown how the Numb-p53 interaction is regulated in cells. We …

Transit of proteins through the endosomal organelle following endocytosis is critical for
regulating the homeostasis of cell-surface proteins and controlling signal transduction pathways. …