Liposomes in ultrasonic drug and gene delivery

SL Huang - Advanced drug delivery reviews, 2008 - Elsevier
Liposome-based drug and gene delivery systems have potential for significant roles in a
variety of therapeutic applications. Recently, liposomes have been used to entrap gas and …

[HTML][HTML] Acoustically active liposomes for drug encapsulation and ultrasound-triggered release

SL Huang, RC MacDonald - Biochimica et Biophysica Acta (BBA) …, 2004 - Elsevier
Acoustically active liposomes (AAL), previously developed as ultrasound contrast agents,
contain small amounts of air. These AAL have potential to carry pharmaceutics and their …

Intravascular ultrasound molecular imaging of atheroma components in vivo

AJ Hamilton, SL Huang, D Warnick, M Rabbat… - Journal of the American …, 2004 - jacc.org
Objectives : Our purpose was to quantitate and confirm specific echogenic immunoliposome
(ELIP) atheroma component enhancement in vivo. Background : Targeted ELIPs for …

Nitric oxide-loaded echogenic liposomes for nitric oxide delivery and inhibition of intimal hyperplasia

SL Huang, PH Kee, H Kim, MR Moody… - Journal of the American …, 2009 - jacc.org
Objectives : We sought to develop a new bioactive gas-delivery method by the use of echogenic
liposomes (ELIP) as the gas carrier. Background : Nitric oxide (NO) is a bioactive gas …

Left ventricular thrombus enhancement after intravenous injection of echogenic immunoliposomes: studies in a new experimental model

A Hamilton, SL Huang, D Warnick, A Stein, M Rabbat… - Circulation, 2002 - Am Heart Assoc
Background— Targeted echogenic immunoliposomes (ELIPs) for ultrasound enhancement
of atheroma components have been developed. To date, ELIP delivery has been intra-arterial…

Ultrasound-enhanced thrombolysis with tPA-loaded echogenic liposomes

GJ Shaw, JM Meunier, SL Huang, CJ Lindsell… - Thrombosis research, 2009 - Elsevier
BACKGROUND AND PURPOSE: Currently, the only FDA-approved therapy for acute ischemic
stroke is the administration of recombinant tissue plasminogen activator (tPA). Echogenic …

Physical correlates of the ultrasonic reflectivity of lipid dispersions suitable as diagnostic contrast agents

SL Huang, AJ Hamilton, E Pozharski, A Nagaraj… - Ultrasound in medicine …, 2002 - Elsevier
The objective of this study was to determine the physical basis of ultrasound (US) reflectivity
of echogenic lipid dispersions. These dispersions were made using a process previously …

Passive imaging with pulsed ultrasound insonations

…, MT Burgess, JA Kopechek, SL Huang… - The Journal of the …, 2012 - pubs.aip.org
Previously, passive cavitation imaging has been described in the context of continuous-wave
high-intensity focused ultrasound thermal ablation. However, the technique has potential …

Broadband attenuation measurements of phospholipid-shelled ultrasound contrast agents

…, K Radhakrishnan, JK Griffin, SL Huang… - Ultrasound in medicine …, 2014 - Elsevier
The aim of this study was to characterize the frequency-dependent acoustic attenuation of
three phospholipid-shelled ultrasound contrast agents (UCAs): Definity, MicroMarker and …

In vivo therapeutic gas delivery for neuroprotection with echogenic liposomes

…, J Aronowski, CK Holland, DD McPherson, SL Huang - Circulation, 2010 - Am Heart Assoc
Background— Ischemia-related neurological injury is a primary cause of stroke disability.
Studies have demonstrated that xenon (Xe) may have potential as an effective and nontoxic …