Aminoacyl tRNA synthetases and their connections to disease
SG Park, P Schimmel, S Kim - Proceedings of the National Academy of …, 2008 - pnas.org
Aminoacylation of transfer RNAs establishes the rules of the genetic code. The reactions
are catalyzed by an ancient group of 20 enzymes (one for each amino acid) known as …
are catalyzed by an ancient group of 20 enzymes (one for each amino acid) known as …
Aminoacyl-tRNA synthetase complexes: beyond translation
SW Lee, BH Cho, SG Park, S Kim - Journal of cell science, 2004 - journals.biologists.com
Although aminoacyl-tRNA synthetases (ARSs) are housekeeping enzymes essential for protein
synthesis, they can play non-catalytic roles in diverse biological processes. Some ARSs …
synthesis, they can play non-catalytic roles in diverse biological processes. Some ARSs …
Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers
SG Park, KL Ewalt, S Kim - Trends in biochemical sciences, 2005 - cell.com
Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that join amino acids to tRNAs,
thereby linking the genetic code to specific amino acids. Once considered a class of ‘…
thereby linking the genetic code to specific amino acids. Once considered a class of ‘…
Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response
Although aminoacyl-tRNA synthetases (ARSs) are essential for protein synthesis, they also
function as regulators and signaling molecules in diverse biological processes. Here, we …
function as regulators and signaling molecules in diverse biological processes. Here, we …
Metabolic Tumor Volume of [18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Predicts Short-Term Outcome to Radiotherapy With or …
Purpose: This study aimed to investigate whether metabolic tumor volume (MTV) measured
from [ 18 F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-…
from [ 18 F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-…
Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis
SG Park, YS Kang, YH Ahn, SH Lee, KR Kim… - Journal of Biological …, 2002 - jbc.org
Mammalian aminoacyl tRNA synthetases form a macromolecular protein complex with three
non-enzymatic cofactors. Among these factors, p43 is also secreted to work as a cytokine on …
non-enzymatic cofactors. Among these factors, p43 is also secreted to work as a cytokine on …
A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes
An auxiliary factor of mammalian multi-aminoacyl-tRNA synthetases, p43, is thought to be a
precursor of endothelial monocyte-activating polypeptide II (EMAP II) that triggers …
precursor of endothelial monocyte-activating polypeptide II (EMAP II) that triggers …
Efficient high-energy pulse-train generation using a 2^ n-pulse michelson interferometer
We demonstrate a novel, Michelson-based, ultrafast multiplexer with a throughput approaching
100% for a polarization-multiplexed train and 50% for a linearly polarized train, which is …
100% for a polarization-multiplexed train and 50% for a linearly polarized train, which is …
Nucleolar localization of human Methionyl–Trna Synthetase and its role in ribosomal RNA synthesis
Human aminoacyl–tRNA synthetases (ARSs) are normally located in cytoplasm and are
involved in protein synthesis. In the present work, we found that human methionyl–tRNA …
involved in protein synthesis. In the present work, we found that human methionyl–tRNA …
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
Y Kise, SW Lee, SG Park, S Fukai, T Sengoku… - Nature structural & …, 2004 - nature.com
Human tryptophanyl-tRNA synthetase (TrpRS) is secreted into the extracellular region of
vascular endothelial cells. The splice variant form (mini TrpRS) functions in vascular endothelial …
vascular endothelial cells. The splice variant form (mini TrpRS) functions in vascular endothelial …