Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by
loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent feature of the …

Depriving cells of nutrients triggers an energetic crisis, which is resolved by metabolic rewiring
and organelle reorganization. Primary cilia are microtubule-based organelles at the cell …

Renal cell carcinomas (RCCs) are common cancers diagnosed in more than 350,000 people
each year worldwide. Several pathways are de-regulated in RCCs, including mTORC1. …

Primary hyperoxaluria type I (PH1) is an autosomal-recessive inborn error of liver metabolism
caused by alanine:glyoxylate aminotransferase (AGT) deficiency. In silico modeling of liver …

The Intravenous Glucose Tolerance Test is an experimental procedure used to study the
glucose-insulin endocrine regulatory system. An open problem is to construct a model …

Inborn errors of metabolism (IEM) are genetic diseases caused by mutations in enzymes or
transporters affecting specific metabolic reactions that cause a block in the physiological …

Photosynthesis is the process used by plants, algae and some bacteria to obtain biochemical
energy from sunlight. It is the most important process allowing life on earth. In this work, by …

A workflow for data analysis is introduced to synthesize flux regulation maps of a Metabolic
P system from time series of data observed in laboratory. The procedure is successfully …

A recent methodology to model biochemical systems is here presented. It is based on a
conceptual framework rooted in membrane computing and developed with concepts typical of …

Metabolic reprogramming is a key feature of Autosomal Dominant Polycystic Kidney Disease
(ADPKD) characterized by changes in cellular pathways occurring in response to the …