User profiles for Richard R. Copley

Richard Copley

Sorbonne Université, CNRS UMR 7009, Villefranche-sur-Mer
Verified email at obs-vlfr.fr
Cited by 69405

Functional organization of the yeast proteome by systematic analysis of protein complexes

…, B Huhse, C Leutwein, MA Heurtier, RR Copley… - Nature, 2002 - nature.com
Most cellular processes are carried out by multiprotein complexes. The identification and
analysis of their components provides insight into how the ensemble of expressed proteins (…

SMART: a web-based tool for the study of genetically mobile domains

J Schultz, RR Copley, T Doerks… - Nucleic acids …, 2000 - academic.oup.com
SMART (a Simple Modular Architecture Research Tool) allows the identification and
annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.…

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

…, B Whittle, T Lambe, IS Roberts, RR Copley… - Nature, 2005 - nature.com
Despite the sequencing of the human and mouse genomes, few genetic mechanisms for
protecting against autoimmune disease are currently known. Here we systematically screen the …

SMART 4.0: towards genomic data integration

I Letunic, RR Copley, S Schmidt… - Nucleic acids …, 2004 - academic.oup.com
SMART (Simple Modular Architecture Research Tool) is a web tool ( http://smart.embl.de/ )
for the identification and annotation of protein domains, and provides a platform for the …

SMART 5: domains in the context of genomes and networks

I Letunic, RR Copley, B Pils, S Pinkert… - Nucleic acids …, 2006 - academic.oup.com
The Simple Modular Architecture Research Tool (SMART) is an online resource ( http://smart.embl.de/
) used for protein domain identification and the analysis of protein domain …

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III

…, K Oegema, A Coulson, SJM Jones, RR Copley… - Nature, 2000 - nature.com
Genome sequencing projects generate a wealth of information; however, the ultimate goal
of such projects is to accelerate the identification of the biological function of genes. This …

The InterPro Database, 2003 brings increased coverage and new features

…, RR Copley, E Courcelle, U Das, R Durbin… - Nucleic acids …, 2003 - academic.oup.com
InterPro, an integrated documentation resource of protein families, domains and functional
sites, was created in 1999 as a means of amalgamating the major protein signature …

[HTML][HTML] Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts

DR Mole, C Blancher, RR Copley, PJ Pollard… - Journal of biological …, 2009 - Elsevier
Hypoxia-inducible factor (HIF) controls an extensive range of adaptive responses to hypoxia.
To better understand this transcriptional cascade we performed genome-wide chromatin …

Systematic identification of novel protein domain families associated with nuclear functions

T Doerks, RR Copley, J Schultz, CP Ponting… - Genome …, 2002 - genome.cshlp.org
A systematic computational analysis of protein sequences containing known nuclear domains
led to the identification of 28 novel domain families. This represents a 26% increase in the …

Recent improvements to the SMART domain-based sequence annotation resource

…, J Schultz, R Mott, F Ciccarelli, RR Copley… - Nucleic acids …, 2002 - academic.oup.com
SMART (Simple Modular Architecture Research Tool, http://smart.embl-heidelberg.de ) is a
web-based resource used for the annotation of protein domains and the analysis of domain …