Colorectal cancer (CRC) is one of the most common causes of death, despite decades of
research. Initially considered as a disease due to genetic mutations, it is now viewed as a …

Several histopathological variants of colorectal carcinoma can be distinguished, some associated
with specific molecular profiles. However, in routine practice, ninety/ninety-five percent …

Over the past decade, growing evidence indicates that the tumor microenvironment (TME)
contributes with genomic/epigenomic aberrations of malignant cells to enhance cancer cells …

Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group (DIRECt), …

Background Obesity in postmenopausal women is associated with increased breast cancer
risk, development of more aggressive tumors and resistance to certain anti-breast cancer …

We evaluated intratumoral heterogeneity of 30 ductal breast carcinomas with HER2/neu
amplification, scored by the American Society of Clinical Oncology/ College of American …

Background Cancer-related immune antigens in the tumor microenvironment could represent
an obstacle to agents targeting EGFR “cetuximab” or VEGF “bevacizumab” in metastatic …

The pathologist emerged in the personalized medicine era as a central actor in the
definition of the most adequate diagnostic and therapeutic algorithms. In the last decade, …

Background and Aims EUS-guided through-the-needle biopsy (TTNB) sampling has been
reported to improve diagnostic yield compared with cytology for the evaluation of pancreatic …

We describe a novel bioinformatic and translational pathology approach, gene Signature
Finder Algorithm (gSFA) to identify biomarkers associated with Colorectal Cancer (CRC) …