IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice
J Loebbermann, C Schnoeller, H Thornton, L Durant… - PloS one, 2012 - journals.plos.org
Interleukin (IL-) 10 is a pleiotropic cytokine with broad immunosuppressive functions,
particularly at mucosal sites such as the intestine and lung. Here we demonstrate that
infection of BALB/c mice with respiratory syncytial virus (RSV) induced IL-10 production by
CD4+ and CD8+ T cells in the airways at later time points (eg day 8); a proportion of these
cells also co-produced IFN-γ. Furthermore, RSV infection of IL-10−/− mice resulted in more
severe disease with enhanced weight loss, delayed recovery and greater cell infiltration of …
particularly at mucosal sites such as the intestine and lung. Here we demonstrate that
infection of BALB/c mice with respiratory syncytial virus (RSV) induced IL-10 production by
CD4+ and CD8+ T cells in the airways at later time points (eg day 8); a proportion of these
cells also co-produced IFN-γ. Furthermore, RSV infection of IL-10−/− mice resulted in more
severe disease with enhanced weight loss, delayed recovery and greater cell infiltration of …
[HTML][HTML] Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection
J Loebbermann, H Thornton, L Durant… - Mucosal …, 2012 - Elsevier
The inflammatory response to lung infections must be tightly regulated, enabling pathogen
elimination while maintaining crucial gas exchange. Using recently described “depletion of
regulatory T cell”(DEREG) mice, we found that selective depletion of regulatory T cells
(Tregs) during acute respiratory syncytial virus (RSV) infection enhanced viral clearance but
increased weight loss, local cytokine and chemokine release, and T-cell activation and
cellular influx into the lungs. Conversely, inflammation was decreased when Treg numbers …
elimination while maintaining crucial gas exchange. Using recently described “depletion of
regulatory T cell”(DEREG) mice, we found that selective depletion of regulatory T cells
(Tregs) during acute respiratory syncytial virus (RSV) infection enhanced viral clearance but
increased weight loss, local cytokine and chemokine release, and T-cell activation and
cellular influx into the lungs. Conversely, inflammation was decreased when Treg numbers …
Showing the best results for this search. See all results
