This review focuses on how environmental factors through epigenetics modify disease risk
and health outcomes. Major epigenetic events, such as histone modifications, DNA …

Loss or mutational inactivation of p53 has been shown to lead to abnormal amplification of
centrosomes through deregulation of the centrosome duplication cycle and failure to undergo …

Poly- and perfluoroalkyl substances (PFAS) are manmade synthetic chemicals which have
been in existence for over 70 years. Though they are currently being phased out, their …

In animal cells, duplication of centrosomes and DNA is coordinated. Since CDK2/cyclin E
triggers initiation of both events, activation of CDK2/cyclin E is thought to link these two events. …

We have previously reported that loss of p53 tumor suppressor protein results in centrosome
hyperamplification, which leads to aberrant mitosis and chromosome instability. Since p53 …

The kinase activity of cyclin-dependent kinase 2 (CDK2)-cyclin E is required for centrosomes
to initiate duplication. We have recently found that nucleophosmin (NPM/B23), a …

Human exposure to bisphenol A (BPA) is ubiquitous. Animal studies found that BPA contributes
to development of prostate cancer, but human data are scarce. Our study examined the …

The function of the centrosomes to direct mitotic spindles is critical for accurate chromosome
transmission to daughter cells. Since each daughter cell inherits one centrosome, each …

Centrosome hyperamplification and the consequential mitotic defects contribute to chromosome
instability in cancers. Loss or mutational inactivation of p53 has been shown to induce …

In this study, a development of a novel calcium phosphate-polymer hybrid nanoparticle system
is reported.The nanoparticle system can co-encapsulate and co-deliver a combination of …