A broad but parametrically simple model for a stationary sequence of dependent discrete
random variables is given and several submodels are discussed. The structure of the model is …

IT is well known that 1 per cent of males in institutions for the mentally sub-normal are
chromatin-positive and that the majority of these have an XXY sex chromosome constitution 1 . In …

Data on structural chromosome abnormalities identified during prenatal diagnosis were used
to estimate the number of such abnormalities that would be detectable in an unselected …

Complete or ‘true’ hydatidiform mole, an abnormality of human gestation, is characterized by
hydropic degeneration of all placental villi, marked hypertrophy of the trophoblast, absence …

Publisher Summary This chapter reviews the origin of numerical chromosome abnormalities.
Humans appear to be unique in their very high frequency of numerical chromosome …

PIP: Trisomy, occurring in at least 4% of pregnancies, is the most common chromosome
abnormality in humans. The majority of trisomies are associated with single additional …

ALL available information on the chromosome constitution of human gametes is speculative,
having been obtained by inference from the chromosome constitution of conceptuses that …

By combining elements of two Y-autosome translocations with displaced autosomal breakpoints,
it is possible to produce zygotes heterozygous for a deficiency for the region between …

The preliminary results of an international collaborative study examining premature
menopause in fragile X carriers are presented. A total of 760 women from fragile X families was …

The detection of a low level 45, X cell line during routine cytogenetic analysis in an adult
female can be difficult to interpret. In the absence of recent information regarding loss of the X …