A microfluidics-based scalable approach to generate extracellular vesicles with enhanced therapeutic microRNA loading for intranasal delivery to mouse …
K Wang, US Kumar, N Sadeghipour, TF Massoud… - ACS …, 2021 - ACS Publications
Extracellular vesicles (EVs), including exosomes and microvesicles derived from different
cell sources, are used as promising nanovesicles for delivering therapeutic microRNAs (…
cell sources, are used as promising nanovesicles for delivering therapeutic microRNAs (…
A rationally identified panel of microRNAs targets multiple oncogenic pathways to enhance chemotherapeutic effects in glioblastoma models
N Sadeghipour, SU Kumar, TF Massoud… - Scientific Reports, 2022 - nature.com
Glioblastoma (GBM) is the most common malignant brain tumor. Available treatments have
limited success because most patients develop chemoresistance. Alternative strategies are …
limited success because most patients develop chemoresistance. Alternative strategies are …
A new Nrf2 inhibitor enhances chemotherapeutic effects in glioblastoma cells carrying p53 mutations
R Afjei, N Sadeghipour, SU Kumar, M Pandrala… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM) is the most common and deadliest brain tumor. Currently,
there is no successful treatment available for GBM patients. Different genes are mutated …
there is no successful treatment available for GBM patients. Different genes are mutated …
A multi‐stage fusion framework to classify breast lesions using deep learning and radiomics features computed from four‐view mammograms
Background Developing computer aided diagnosis (CAD) schemes of mammograms to
classify between malignant and benign breast lesions has attracted a lot of research attention …
classify between malignant and benign breast lesions has attracted a lot of research attention …
Prediction of optimal contrast times post-imaging agent administration to inform personalized fluorescence-guided surgery
N Sadeghipour, A Rangnekar… - Journal of …, 2020 - spiedigitallibrary.org
Significance: Fluorescence guidance in cancer surgery (FGS) using molecular-targeted contrast
agents is accelerating, yet the influence of individual patients’ physiology on the optimal …
agents is accelerating, yet the influence of individual patients’ physiology on the optimal …
Improving performance of breast lesion classification using a ResNet50 model optimized with a novel attention mechanism
Background: The accurate classification between malignant and benign breast lesions
detected on mammograms is a crucial but difficult challenge for reducing false-positive recall …
detected on mammograms is a crucial but difficult challenge for reducing false-positive recall …
Immune modulations of the tumor microenvironment in response to phototherapy
TI Valerio, CL Furrer, N Sadeghipour… - Journal of innovative …, 2023 - World Scientific
The tumor microenvironment (TME) promotes pro-tumor and anti-inflammatory metabolisms
and suppresses the host immune system. It prevents immune cells from fighting against …
and suppresses the host immune system. It prevents immune cells from fighting against …
Tumor volume doubling time estimated from digital breast tomosynthesis mammograms distinguishes invasive breast cancers from benign lesions
N Sadeghipour, J Tseng, K Anderson… - European …, 2023 - Springer
Objectives The aim of this study was to determine whether lesion size metrics on consecutive
screening mammograms could predict malignant invasive carcinoma versus benign lesion …
screening mammograms could predict malignant invasive carcinoma versus benign lesion …
Androgen production, uptake, and conversion (APUC) genes define prostate cancer patients with distinct clinical outcomes
HE Bergom, E Boytim, S McSweeney, N Sadeghipour… - JCI insight, 2024 - insight.jci.org
BACKGROUND. Prostate cancer (PC) is driven by aberrant signaling of the androgen
receptor (AR) or its ligands, and androgen deprivation therapies (ADT) are a cornerstone of …
receptor (AR) or its ligands, and androgen deprivation therapies (ADT) are a cornerstone of …
Inhaled Gold Nano‐Star Carriers for Targeted Delivery of Triple Suicide Gene Therapy and Therapeutic MicroRNAs to Lung Metastases: Development and Validation …
…, A Rengaramachandran, N Sadeghipour… - Advanced …, 2022 - Wiley Online Library
Pulmonary metastases pose treatment challenges for many cancers, including triple‐negative
breast cancer (TNBC). A novel suicide gene and therapeutic microRNAs (miRs) …
breast cancer (TNBC). A novel suicide gene and therapeutic microRNAs (miRs) …