A correlation has previously been demonstrated between the presence of the three HMGI
proteins (HMGI, HMGY, and HMGI-C) and the expression of a highly malignant phenotype in …

The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure
and thereby regulate the transcription of several genes by either enhancing or suppressing …

The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The
first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing …

HMGA2 gene amplification and overexpression in human prolactinomas and the development
of pituitary adenomas in HMGA2 transgenic mice showed that HMGA2 plays a crucial role …

Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells in vitro,
promotes neoangiogenesis in vivo and increases the permeability of the vascular endothelium…

Overexpression of the HMGA2 gene is a common feature of neoplastic cells both in experimental
and human models. Intragenic and extragenic HMGA2 rearrangements responsible for …

Type 2 diabetes mellitus is a widespread disease, affecting millions of people globally.
Although genetics and environmental factors seem to have a role, the cause of this metabolic …

The transition between epithelial and mesenchymal phenotype is emerging as a key determinant
of tumor cell invasion and metastasis. It is a plastic process in which epithelial cells first …

Rearrangements of the HMGI-C gene have frequently been detected in human benign
tumors of mesenchymal origin, including lipomas. The HMGI-C protein has three AT-hook …

Glioblastoma (GBM) is an extremely aggressive tumor of the central nervous system, with a
prognosis of 12–15 months and just 3–5% of survival over 5 years. This is mainly because …