User profiles for Monica Fedele
![]() | Monica FedeleIEOS-CNR Verified email at cnr.it Cited by 9754 |
Human colorectal carcinomas express high levels of high mobility group HMGI (Y) proteins
A correlation has previously been demonstrated between the presence of the three HMGI
proteins (HMGI, HMGY, and HMGI-C) and the expression of a highly malignant phenotype in …
proteins (HMGI, HMGY, and HMGI-C) and the expression of a highly malignant phenotype in …
Roles of HMGA proteins in cancer
The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure
and thereby regulate the transcription of several genes by either enhancing or suppressing …
and thereby regulate the transcription of several genes by either enhancing or suppressing …
High level expression of the HMGI (Y) gene during embryonic development.
The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The
first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing …
first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing …
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity
HMGA2 gene amplification and overexpression in human prolactinomas and the development
of pituitary adenomas in HMGA2 transgenic mice showed that HMGA2 plays a crucial role …
of pituitary adenomas in HMGA2 transgenic mice showed that HMGA2 plays a crucial role …
Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors …
…, J Cerutti, A Romano, F Trapasso, M Fedele… - Oncogene, 1995 - europepmc.org
Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells in vitro,
promotes neoangiogenesis in vivo and increases the permeability of the vascular endothelium…
promotes neoangiogenesis in vivo and increases the permeability of the vascular endothelium…
Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas
M Fedele, S Battista, L Kenyon, G Baldassarre… - Oncogene, 2002 - nature.com
Overexpression of the HMGA2 gene is a common feature of neoplastic cells both in experimental
and human models. Intragenic and extragenic HMGA2 rearrangements responsible for …
and human models. Intragenic and extragenic HMGA2 rearrangements responsible for …
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice
Type 2 diabetes mellitus is a widespread disease, affecting millions of people globally.
Although genetics and environmental factors seem to have a role, the cause of this metabolic …
Although genetics and environmental factors seem to have a role, the cause of this metabolic …
The epithelial–mesenchymal transition at the crossroads between metabolism and tumor progression
The transition between epithelial and mesenchymal phenotype is emerging as a key determinant
of tumor cell invasion and metastasis. It is a plastic process in which epithelial cells first …
of tumor cell invasion and metastasis. It is a plastic process in which epithelial cells first …
The Expression of a Truncated HMGI-C Gene Induces Gigantism Associated with Lipomatosis
S Battista, V Fidanza, M Fedele, AJP Klein-Szanto… - Cancer research, 1999 - AACR
Rearrangements of the HMGI-C gene have frequently been detected in human benign
tumors of mesenchymal origin, including lipomas. The HMGI-C protein has three AT-hook …
tumors of mesenchymal origin, including lipomas. The HMGI-C protein has three AT-hook …
Proneural-mesenchymal transition: phenotypic plasticity to acquire multitherapy resistance in glioblastoma
Glioblastoma (GBM) is an extremely aggressive tumor of the central nervous system, with a
prognosis of 12–15 months and just 3–5% of survival over 5 years. This is mainly because …
prognosis of 12–15 months and just 3–5% of survival over 5 years. This is mainly because …