Background Patients with Birt-Hogg-Dubé (BHD) syndrome harbor germline mutations in
the BHD tumor suppressor gene that are associated with an increased risk for kidney cancer. …

Control of cellular metabolism is critical for efficient cell function, although little is known
about the interplay between cell subset–specific metabolites in situ, especially in the tumor …

Abstract Analysis of the Polyp Prevention Trial showed an association between an
isorhamnetin-rich diet and a reduced risk of advanced adenoma recurrence; however, the …

Purpose: Brain metastases of breast cancer contribute significantly to patient morbidity and
mortality. We have tested pazopanib, a recently approved antiangiogenic drug that targets …

Key findings from studies with this preclinical mouse model of TFE3-RCC underscore the
potential for RET as a therapeutic target for treatment of patients with TFE3-RCC, and suggest …

In this paper, we report a new method to prepare and characterize a contrast agent based
on a fourth-generation (G4) polyamidoamine (PAMAM) dendrimer conjugated to the …

The development of improvements in magnetic resonance imaging (MRI) that would enhance
sensitivity, leading to earlier detection of cancer and visualization of metastatic disease, is …

Early detection of precancerous tissue has significantly improved survival of most cancers
including colorectal cancer (CRC). Animal models designed to study the early stages of …

The development of effective cancer therapies has been hampered, in part, by the inability
to non-invasively follow tumor progression from the initial cancerous lesion through to …

BACKGROUND Mouse prostate cancer modeling presents unique obstacles to the study of
spontaneous tumor initiation and progression due to the anatomical location of the tissue. …