Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys
…, R Leighty, M Yao, M Bernardo, L Ileva… - Journal of the …, 2008 - academic.oup.com
Background Patients with Birt-Hogg-Dubé (BHD) syndrome harbor germline mutations in
the BHD tumor suppressor gene that are associated with an increased risk for kidney cancer. …
the BHD tumor suppressor gene that are associated with an increased risk for kidney cancer. …
Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors
JM Weiss, LC Davies, M Karwan, L Ileva… - The Journal of …, 2018 - Am Soc Clin Investig
Control of cellular metabolism is critical for efficient cell function, although little is known
about the interplay between cell subset–specific metabolites in situ, especially in the tumor …
about the interplay between cell subset–specific metabolites in situ, especially in the tumor …
Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin
SM Saud, MR Young, YL Jones-Hall, L Ileva… - Cancer research, 2013 - AACR
Abstract Analysis of the Polyp Prevention Trial showed an association between an
isorhamnetin-rich diet and a reduced risk of advanced adenoma recurrence; however, the …
isorhamnetin-rich diet and a reduced risk of advanced adenoma recurrence; however, the …
Pazopanib Reveals a Role for Tumor Cell B-Raf in the Prevention of HER2+ Breast Cancer Brain Metastasis
B Gril, D Palmieri, Y Qian, DD Smart, L Ileva… - Clinical Cancer …, 2011 - AACR
Purpose: Brain metastases of breast cancer contribute significantly to patient morbidity and
mortality. We have tested pazopanib, a recently approved antiangiogenic drug that targets …
mortality. We have tested pazopanib, a recently approved antiangiogenic drug that targets …
TFE3 Xp11. 2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease
…, Y Satou, N Morris, BO Karim, L Ileva… - Molecular Cancer …, 2019 - AACR
Key findings from studies with this preclinical mouse model of TFE3-RCC underscore the
potential for RET as a therapeutic target for treatment of patients with TFE3-RCC, and suggest …
potential for RET as a therapeutic target for treatment of patients with TFE3-RCC, and suggest …
A new approach in the preparation of dendrimer-based bifunctional diethylenetriaminepentaacetic acid MR contrast agent derivatives
…, H Xu, CAS Regino, M Bernardo, L Ileva… - Bioconjugate …, 2009 - ACS Publications
In this paper, we report a new method to prepare and characterize a contrast agent based
on a fourth-generation (G4) polyamidoamine (PAMAM) dendrimer conjugated to the …
on a fourth-generation (G4) polyamidoamine (PAMAM) dendrimer conjugated to the …
A tumor-targeted nanodelivery system to improve early MRI detection of cancer
The development of improvements in magnetic resonance imaging (MRI) that would enhance
sensitivity, leading to earlier detection of cancer and visualization of metastatic disease, is …
sensitivity, leading to earlier detection of cancer and visualization of metastatic disease, is …
Monitoring of tumor promotion and progression in a mouse model of inflammation-induced colon cancer with magnetic resonance colonography
MR Young, LV Ileva, M Bernardo, LA Riffle, YL Jones… - Neoplasia, 2009 - Elsevier
Early detection of precancerous tissue has significantly improved survival of most cancers
including colorectal cancer (CRC). Animal models designed to study the early stages of …
including colorectal cancer (CRC). Animal models designed to study the early stages of …
Contrast-enhanced in vivo imaging of breast and prostate cancer cells by MRI
The development of effective cancer therapies has been hampered, in part, by the inability
to non-invasively follow tumor progression from the initial cancerous lesion through to …
to non-invasively follow tumor progression from the initial cancerous lesion through to …
In vivo magnetic resonance volumetric and spectroscopic analysis of mouse prostate cancer models
…, CD Chien, T Newell, K Johnson, L Ileva… - The …, 2006 - Wiley Online Library
BACKGROUND Mouse prostate cancer modeling presents unique obstacles to the study of
spontaneous tumor initiation and progression due to the anatomical location of the tissue. …
spontaneous tumor initiation and progression due to the anatomical location of the tissue. …