Microarray analysis of microbial virulence factors

V Chizhikov, A Rasooly, K Chumakov… - Applied and …, 2001 - Am Soc Microbiol
Hybridization with oligonucleotide microchips (microarrays) was used for discrimination
among strains of Escherichia coli and other pathogenic enteric bacteria harboring various …

Identification of Listeria Species by Microarray-Based Assay

D Volokhov, A Rasooly, K Chumakov… - Journal of Clinical …, 2002 - Am Soc Microbiol
We have developed a rapid microarray-based assay for the reliable detection and
discrimination of six species of the Listeria genus: L. monocytogenes, L. ivanovii, L. innocua, L. …

Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics

K Chumakov, MS Avidan, CS Benn… - Proceedings of the …, 2021 - National Acad Sciences
The COVID-19 pandemic triggered an unparalleled pursuit of vaccines to induce specific
adaptive immunity, based on virus-neutralizing antibodies and T cell responses. Although …

Medical applications of microarray technologies: a regulatory science perspective

…, LJ Lesko, RK Puri, SI Gutman, K Chumakov… - Nature …, 2002 - nature.com
The potential medical applications of microarrays have generated much excitement, and
some skepticism, within the biomedical community. Some researchers have suggested that …

Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine.

KM Chumakov, LB Powers… - Proceedings of the …, 1991 - National Acad Sciences
Production of live attenuated oral poliomyelitis vaccine (OPV) requires rigorous neurovirulence
safety testing of each vaccine lot, currently carried out in monkeys. It has been reported …

Can existing live vaccines prevent COVID-19?

K Chumakov, CS Benn, P Aaby, S Kottilil, R Gallo - Science, 2020 - science.org
Prophylactic vaccination is the most effective intervention to protect against infectious diseases.
The commonly accepted paradigm is that immunization with both attenuated virus (live …

A full-length infectious cDNA clone of Zika virus from the 2015 epidemic in Brazil as a genetic platform for studies of virus-host interactions and vaccine development

…, H Manukyan, SS Whitehead, M Laassri, K Chumakov… - MBio, 2016 - Am Soc Microbiol
An arthropod-borne virus, Zika virus (ZIKV), has recently emerged as a major human
pathogen. Associated with complications during perinatal development and Guillain-Barré …

Proteolytic cleavage of the p65-RelA subunit of NF-κB during poliovirus infection

N Neznanov, KM Chumakov, L Neznanova… - Journal of Biological …, 2005 - ASBMB
Activation of NF-κB during viral infection is one of the critical elements in innate immune
response. Several virus-specific factors, such as double-stranded RNA, can trigger host defense …

The role of trained immunity in COVID-19: Lessons for the next pandemic

…, LAB Joosten, M Arditi, K Chumakov… - Cell Host & Microbe, 2023 - cell.com
Trained immunity is a long-term increase in responsiveness of innate immune cells, induced
by certain infections and vaccines. During the last 3 years of the COVID-19 pandemic, …

Expert review on poliovirus immunity and transmission

…, MA Pallansch, KM Chumakov… - Risk …, 2013 - Wiley Online Library
Successfully managing risks to achieve wild polioviruses (WPVs) eradication and address
the complexities of oral poliovirus vaccine (OPV) cessation to stop all cases of paralytic …