We show here that fundamental aspects of antitumor immunity in mice are significantly
influenced by ambient housing temperature. Standard housing temperature for laboratory mice in …

Immunotherapy has expanded treatment options for cancers with historically poor outcomes,
yet a significant proportion of patients still fail to achieve durable clinical benefit. We defined …

The immune context of tumors has significant prognostic value and is predictive of responsiveness
to several forms of therapy, including immunotherapy. We report here that CD8 + T-…

Long conserved mechanisms maintain homeostasis in living creatures in response to a variety
of stresses. However, continuous exposure to stress can result in unabated production of …

Cancer research relies heavily on murine models for evaluating the anti-tumour efficacy of
therapies. Here we show that the sensitivity of several pancreatic tumour models to cytotoxic …

There is a growing body of evidence supporting the synergistic roles of radiotherapy and
immunotherapy in the treatment of malignancy. Published case studies of the abscopal effect …

The ability of dendritic cells (DCs) to stimulate and regulate T cells is critical to effective anti-tumor
immunity. Therefore, it is important to fully recognize any inherent factors which may …

Purpose: Clinical trials combining hyperthermia with radiation and/or chemotherapy for cancer
treatment have resulted in improved overall survival and control of local recurrences. The …

Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic
cell transplantation, a potentially curative therapy for hematologic diseases. It has long been …

There is widespread recognition among both patients and caregivers that breast cancer
patients often experience debilitating deficiencies in their ability to achieve thermal comfort, …