User profiles for John Hwa
![]() | John HwaYale Verified email at yale.edu Cited by 11177 |
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences
…, EE Gardiner, AI Lee, WH Tang, J Hwa - Nature cardiovascular …, 2022 - nature.com
Platelets have been shown to be associated with pathophysiological processes beyond
thrombosis, demonstrating critical additional roles in homeostatic processes, such as immune …
thrombosis, demonstrating critical additional roles in homeostatic processes, such as immune …
Role of platelet mitochondria: life in a nucleus-free zone
Platelets are abundant, small, anucleate circulating cells, serving many emerging
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis, injury …
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis, injury …
Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome
…, N Rioux-Leclerc, GW Moeckel, MC Gubler, J Hwa… - Nature …, 2013 - nature.com
Pathologic thrombosis is a major cause of mortality. Hemolytic-uremic syndrome (HUS)
features episodes of small-vessel thrombosis resulting in microangiopathic hemolytic anemia, …
features episodes of small-vessel thrombosis resulting in microangiopathic hemolytic anemia, …
α1-Adrenergic Receptor Subtypes: Molecular Structure, Function, and Signaling
The a, ARs are important mediators of sympathetic nervous system responses, particularly
those involved in cardiovascular homeostasis, such as arteriolar smooth muscle constriction …
those involved in cardiovascular homeostasis, such as arteriolar smooth muscle constriction …
Aldose reductase, oxidative stress, and diabetic mellitus
Diabetes mellitus (DM) is a complex metabolic disorder arising from lack of insulin production
or insulin resistance (Diagnosis and classification of diabetes mellitus, 2007 ). DM is a …
or insulin resistance (Diagnosis and classification of diabetes mellitus, 2007 ). DM is a …
Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study
Background An important feature of severe acute respiratory syndrome coronavirus 2
pathogenesis is COVID-19-associated coagulopathy, characterised by increased thrombotic and …
pathogenesis is COVID-19-associated coagulopathy, characterised by increased thrombotic and …
G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling
The hedgehog (Hh) signalling pathway has an evolutionarily conserved role in patterning
fields of cells during metazoan development, and is inappropriately activated in cancer 1 , 2 . …
fields of cells during metazoan development, and is inappropriately activated in cancer 1 , 2 . …
A neutrophil activation signature predicts critical illness and mortality in COVID-19
Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-19,
but the mechanisms involved remain poorly understood. We carried out proteomic …
but the mechanisms involved remain poorly understood. We carried out proteomic …
Inducing mitophagy in diabetic platelets protects against severe oxidative stress
Diabetes mellitus ( DM ) is a growing international concern. Considerable mortality and
morbidity associated with diabetes mellitus arise predominantly from thrombotic cardiovascular …
morbidity associated with diabetes mellitus arise predominantly from thrombotic cardiovascular …