Aicardi-Goutières syndrome (AGS) presents as a severe neurological brain disease and is
a genetic mimic of the sequelae of transplacentally acquired viral infection 1 , 2 . Evidence …

Background Donor availability and transplantation-related risks limit the broad use of
allogeneic hematopoietic-cell transplantation in patients with transfusion-dependent β-thalassemia…

<p id="p001">Sickle cell disease results from a homozygous missense mutation in the β-globin
gene that causes polymerization of hemoglobin S. Gene therapy for patients with this …

B19 virus is a human virus belonging to the genus Erythrovirus. The genetic diversity
among B19 virus isolates has been reported to be very low, with less than 2% nucleotide …

JAK Inhibition in the Aicardi–Goutières Syndrome Patients with the Aicardi–Goutières
syndrome, an autosomal recessive disorder that affects the central nervous system, immune …

BACKGROUND & AIMS: Although hepatitis C virus (HCV) can be grown in the
hepatocarcinoma-derived cell line Huh-7, a cell-culture model is needed that supports its complete, …

… Dominique Salmon-Ceron, a, b, 1, ⁎ Dorsaf Slama, a, 1 Thomas De Broucker, c Marina
Karmochkine, a Juliette Pavie, a Emmanuel Sorbets, d, b Nicolas Etienne, a, b Dominique …

Objective To assess a new adenovirus-based immunotherapy as a novel treatment approach
to chronic hepatitis B (CHB). Methods TG1050 is a non-replicative adenovirus serotype 5 …

Background PRKDC encodes for DNA-dependent protein kinase catalytic subunit (DNA-PKcs),
a kinase that forms part of a complex (DNA-dependent protein kinase [DNA-PK]) crucial …

Objective Recently approved direct acting antivirals provide transformative therapies for
chronic hepatitis C virus (HCV) infection. The major clinical challenge remains to identify the …