Despite gains in survival, outcomes for patients with metastatic or recurrent rhabdomyosarcoma
remain dismal. In a collaboration between the National Cancer Institute, Children's …

Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor
responses in hematologic malignancies, but tumor regression has rarely occurred using CARs …

Chimeric antigen receptor (CAR) T cells targeting CD19 mediate potent effects in relapsed
and/or refractory pre–B cell acute lymphoblastic leukemia (B-ALL), but antigen loss is a …

The Ewing sarcoma family of tumors (EFT) is a group of highly malignant small round blue
cell tumors occurring in children and young adults. We report here the largest genomic survey …

PURPOSE Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood.
Despite aggressive therapy, the 5-year survival rate for patients with metastatic or recurrent …

Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells
targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell …

Alveolar rhabdomyosarcoma is a life-threatening myogenic cancer of children and adolescent
young adults, driven primarily by the chimeric transcription factor PAX3–FOXO1. The …

Despite high remission rates following CAR-T cell therapy in B-ALL, relapse due to loss of
the targeted antigen is increasingly recognized as a mechanism of immune escape. We …

Synovial sarcoma (SS) is defined by the hallmark SS18-SSX fusion oncoprotein, which
renders BAF complexes aberrant in two manners: gain of SSX to the SS18 subunit and …

A deeper understanding of the metastatic process is required for the development of new
therapies that improve patient survival. Metastatic tumor cell growth and survival in distant …