Objective: Persistent air leakage following pulmonary resection is a major limiting factor for
discharge from hospital. The aim of this study was to evaluate the sealing capacity of …

Objectives The present investigation explored the ability of fosfomycin to penetrate lung
tissue of septic patients by utilizing the microdialysis technique. Methods After microdialysis …

Background Hypoxia-induced genes are potential targets in cancer therapy. Responses to
hypoxia have been extensively studied in vitro, however, they may differ in vivo due to the …

Background Severe pulmonary hypertension (PH) is prognostically highly relevant in
patients with COPD. The criteria for severe PH have been defined based on hemodynamic …

A central feature of progressive vascular remodeling is altered smooth muscle cell (SMC)
homeostasis; however, the understanding of how different cell populations contribute to this …

Cannabinoid (CB) receptors (CB 1 and CB 2 ) are expressed on cancer cells and their
expression influences carcinogenesis in various tumor entities. Cells of the tumor …

Neutrophils have been described as a phenotypically heterogeneous cell type that possess
both pro- and anti-tumor properties. Recently, a subset of neutrophils isolated from the …

Lung cancer is the leading cause of cancer deaths worldwide; survival times are poor
despite therapy. The role of the two-pore domain K + (K2P) channel TASK-1 (KCNK3) in lung …

As powerful vasodilators, prostacyclin analogues are presently the mainstay in the
treatment of severe pulmonary arterial hypertension. Although the hemodynamic effects of …

In the last two decades, various therapies have been introduced for lung carcinoma patients,
including tyrosine-kinase inhibitors for different mutations. While some of them are specific …