Cytokine profiles associated with acute COVID-19 and long COVID-19 syndrome

…, ALS da Silva, MM Leite, FP da Costa… - Frontiers in cellular …, 2022 - frontiersin.org
The duration and severity of COVID-19 are related to age, comorbidities, and cytokine
synthesis. This study evaluated the impact of these factors on patients with clinical presentations …

Immunogenetic Profile Associated with Patients Living with HIV-1 and Epstein–Barr Virus (EBV) in the Brazilian Amazon Region

IB Costa, MN Santana-da-Silva, PY Nogami… - Viruses, 2024 - mdpi.com
Viral coinfection among HIV-positive patients, coupled with the development of AIDS, remains
a major public health problem. The synergism between the presence of HIV and other …

Genotypes of Epstein–Barr virus (EBV1/EBV2) in individuals with infectious mononucleosis in the metropolitan area of Belém, Brazil, between 2005 and 2016

TAF Monteiro, IB Costa, IB Costa… - Brazilian Journal of …, 2020 - SciELO Brasil
Two types of Epstein Barr virus (EBV1/EBV2) have been shown to infect humans. Although
their genomes are similar, the regions containing the EBNA genes differ. This study aimed to …

Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α

…, IB Costa, IMV Cayres-Vallinoto, I Brasil-Costa… - Scientific Reports, 2024 - nature.com
The cGAS-STING pathway appears to contribute to dysregulated inflammation during
coronavirus disease 2019 (COVID-19); however, inflammatory factors related to long COVID are …

Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19

…, JC Lopes, EF Santos, FP da Costa… - Frontiers in …, 2023 - frontiersin.org
Introduction Mannose-binding lectin (MBL) promotes opsonization, favoring phagocytosis
and activation of the complement system in response to different microorganisms, and may …

Association of polymorphisms of IL-6 pathway genes (IL6, IL6R and IL6ST) with COVID-19 severity in an Amazonian population

…, CP Silva, IB Costa, JAL Nunes, IB Costa… - Viruses, 2023 - mdpi.com
Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an
important regulator of the cytokine storm. Hence, the evaluation of the influence of …

Epstein–Barr Virus (EBV) Genotypes Associated with the Immunopathological Profile of People Living with HIV-1: Immunological Aspects of Primary EBV Infection

LMS Pereira, ES França, IB Costa, IT Lima, ABC Freire… - Viruses, 2022 - mdpi.com
Background: The aim of the present study was to evaluate the immunological profile of adult
HIV-1 + patients coinfected with primary Epstein–Barr virus (EBV) infection who were free of …

Lower genetic variability of HIV-1 and antiretroviral drug resistance in pregnant women from the state of Pará, Brazil

LFA Machado, IB Costa, MN Folha, ALB da Luz… - BMC Infectious …, 2017 - Springer
Background The present study aimed to describe the genetic diversity of HIV-1, as well as
the resistance profile of the viruses identified in HIV-1 infected pregnant women under …

Epidemiological risk factors associated with primary infection by Epstein–Barr virus in HIV-1-positive subjects in the Brazilian Amazon region

LMS Pereira, E dos Santos França, IB Costa, IT Lima… - Scientific Reports, 2021 - nature.com
To identify the prevalence and risk factors for primary Epstein–Barr virus (EBV) infection in
human immunodeficiency virus (HIV)-1-positive adult treatment-naïve patients between …

DRB1 locus alleles of HLA class II are associated with modulation of the immune response in different serological profiles of HIV-1/Epstein-Barr virus coinfection in the …

LMS Pereira, E dos Santos França, IB Costa… - Frontiers in …, 2024 - frontiersin.org
Background Epstein–Barr virus (EBV) infection involves distinct clinical and serological
profiles. We evaluated the frequency of alleles of locus DRB1 of HLA class II in different …