One pressing need in the area of public health is timely, accurate, and complete reporting of deaths and the diseases or conditions leading up to them. Fast Healthcare Interoperability Resources (FHIR) is a new HL7 interoperability standard for electronic health record, while Sustainable Medical Applications and Reusable Technologies (SMART)-on-FHIR enables third-party app development that can work “out of the box.” This paper demonstrates the feasibility of developing SMART-on-FHIR applications that enables medical professionals to perform timely and accurate death reporting within multiple different USA State jurisdictions. We explored how the information on a standard certificate of death can be mapped to resources defined in the FHIR standard Draft Standard for Trial Use Version 2 and common profiles. We also demonstrated analytics for potentially improving the accuracy and completeness of mortality reporting data.