The discovery of novel bioactive molecules advances our systems‐level understanding of
biological processes and is crucial for innovation in drug development. For this purpose, the …

Calcification plays a key role in biological processes, and breakdown of the regulatory
mechanism results in a pathological state such as ectopic calcification. We hypothesized that …

Background Epidermal growth factor receptor (EGFR) plays a pivotal role in the pathophysiology
of esophageal squamous cell carcinoma (ESCC). However, the clinical effects of EGFR …

5-Fluorouracil (5-FU) is a key drug for the treatment of esophageal squamous cell carcinoma
(ESCC); however, resistance to it remains a critical limitation to its clinical use. To clarify the …

Alcohol consumption is the key risk factor for the development of esophageal squamous cell
carcinoma (ESCC), and acetaldehyde, a metabolite of alcohol, is an alcohol-derived major …

Vascular calcification, an ectopic calcification exacerbated by aging and renal dysfunction,
is closely associated with cardiovascular disease. However, early detection indicators are …

Esophageal squamous cell carcinoma (ESCC) is a disease characterized by a high mutation
rate of the TP53 gene, which plays pivotal roles in the DNA damage response (DDR) and …

Despite advanced therapeutics, esophageal squamous cell carcinoma (ESCC) remains one
of the deadliest cancers. Here, we propose a novel therapeutic strategy based on synthetic …

Mandibular retrognathism occurs by insufficient mandibular growth and causes several
issues, such as respiratory difficulty and diminished masticatory function. At present, functional …

Clinical cancer genome sequencing detects oncogenic variants that are potential targets for
cancer treatment, but it also detects variants of unknown significance. These variants may …