Birds have played a central role in many biological disciplines, particularly ecology,
evolution, and behavior. The chicken, as a model vertebrate, also represents an important …

Sphingolipid biosynthesis commences with the condensation of L-serine and palmitoyl-CoA
to produce 3-ketodihydrosphingosine (KDS). This reaction is catalysed by the PLP-…

The Scottish Structural Proteomics Facility was funded to develop a laboratory scale
approach to high throughput structure determination. The effort was successful in that over 40 …

Proteogenomics has the potential to advance genome annotation through high quality peptide
identifications derived from mass spectrometry experiments, which demonstrate a given …

The ability to rank proteins by their likely success in crystallization is useful in current Structural
Biology efforts and in particular in high-throughput Structural Genomics initiatives. We …

Target selection and ranking is fundamental to structural genomics. We present a Z-score
scale, the “OB-Score”, to rank potential targets by their predicted propensity to produce …

Production of diffracting crystals is a critical step in determining the three‐dimensional structure
of a protein by X‐ray crystallography. Computational techniques to rank proteins by their …

Long-term nonprogression during acute HIV infection has been strongly associated with
HLA-B* 5701 or HLA-B* 5703. In this study, we present the high resolution crystal structures of …

… Similarly to the data management controller, a threshold τ m is also used to accommodate
overflows, thus y m = σ ′ σ ⋅ τ m . The system is in a non-steady state if the amount of …

Cell identity is governed by gene expression, regulated by transcription factor (TF) binding
at cis-regulatory modules. Decoding the relationship between TF binding patterns and gene …