User profiles for Ian M. Overton
![]() | Ian OvertonReader (Associate Professor) of Bioinformatics, Queen's University Belfast Verified email at qub.ac.uk Cited by 5264 |
[HTML][HTML] A comprehensive collection of chicken cDNAs
Birds have played a central role in many biological disciplines, particularly ecology,
evolution, and behavior. The chicken, as a model vertebrate, also represents an important …
evolution, and behavior. The chicken, as a model vertebrate, also represents an important …
The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis
…, LG Carter, KA Johnson, IM Overton, M Dorward… - Journal of molecular …, 2007 - Elsevier
Sphingolipid biosynthesis commences with the condensation of L-serine and palmitoyl-CoA
to produce 3-ketodihydrosphingosine (KDS). This reaction is catalysed by the PLP-…
to produce 3-ketodihydrosphingosine (KDS). This reaction is catalysed by the PLP-…
The Scottish structural proteomics facility: targets, methods and outputs
…, C Cozens, H Falconer, H Powers, IM Overton… - Journal of structural and …, 2010 - Springer
The Scottish Structural Proteomics Facility was funded to develop a laboratory scale
approach to high throughput structure determination. The effort was successful in that over 40 …
approach to high throughput structure determination. The effort was successful in that over 40 …
Addressing statistical biases in nucleotide-derived protein databases for proteogenomic search strategies
P Blakeley, IM Overton, SJ Hubbard - Journal of proteome …, 2012 - ACS Publications
Proteogenomics has the potential to advance genome annotation through high quality peptide
identifications derived from mass spectrometry experiments, which demonstrate a given …
identifications derived from mass spectrometry experiments, which demonstrate a given …
ParCrys: a Parzen window density estimation approach to protein crystallization propensity prediction
IM Overton, G Padovani, MA Girolami… - Bioinformatics, 2008 - academic.oup.com
The ability to rank proteins by their likely success in crystallization is useful in current Structural
Biology efforts and in particular in high-throughput Structural Genomics initiatives. We …
Biology efforts and in particular in high-throughput Structural Genomics initiatives. We …
[HTML][HTML] A normalised scale for structural genomics target ranking: the OB-Score
IM Overton, GJ Barton - FEBS letters, 2006 - Elsevier
Target selection and ranking is fundamental to structural genomics. We present a Z-score
scale, the “OB-Score”, to rank potential targets by their predicted propensity to produce …
scale, the “OB-Score”, to rank potential targets by their predicted propensity to produce …
XANNpred: Neural nets that predict the propensity of a protein to yield diffraction‐quality crystals
IM Overton, CAJ van Niekerk… - … : Structure, Function, and …, 2011 - Wiley Online Library
Production of diffracting crystals is a critical step in determining the three‐dimensional structure
of a protein by X‐ray crystallography. Computational techniques to rank proteins by their …
of a protein by X‐ray crystallography. Computational techniques to rank proteins by their …
Structures of three HIV-1 HLA-B* 5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression
GBE Stewart-Jones, G Gillespie, IM Overton… - The Journal of …, 2005 - journals.aai.org
Long-term nonprogression during acute HIV infection has been strongly associated with
HLA-B* 5701 or HLA-B* 5703. In this study, we present the high resolution crystal structures of …
HLA-B* 5701 or HLA-B* 5703. In this study, we present the high resolution crystal structures of …
Using simple pid-inspired controllers for online resilient resource management of distributed scientific workflows
… Similarly to the data management controller, a threshold τ m is also used to accommodate
overflows, thus y m = σ ′ σ ⋅ τ m . The system is in a non-steady state if the amount of …
overflows, thus y m = σ ′ σ ⋅ τ m . The system is in a non-steady state if the amount of …
Functional transcription factor target networks illuminate control of epithelial remodelling
Cell identity is governed by gene expression, regulated by transcription factor (TF) binding
at cis-regulatory modules. Decoding the relationship between TF binding patterns and gene …
at cis-regulatory modules. Decoding the relationship between TF binding patterns and gene …