User profiles for Harsha Krishnareddy

Harsha Krishnareddy

IBM Research - Almaden
Verified email at us.ibm.com
Cited by 156

Monitoring the microbiome for food safety and quality using deep shotgun sequencing

…, B Kawas, M Davis, RJ Prill, H Krishnareddy… - npj Science of …, 2021 - nature.com
In this work, we hypothesized that shifts in the food microbiome can be used as an indicator
of unexpected contaminants or environmental changes. To test this hypothesis, we …

Functional genomics platform, a cloud-based platform for studying microbial life at scale

EE Seabolt, G Nayar, H Krishnareddy… - IEEE/ACM …, 2020 - ieeexplore.ieee.org
The rapid growth in biological sequence data is revolutionizing our understanding of genotypic
diversity and challenging conventional approaches to informatics. With the increasing …

A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6 …

TM Anil, A Dandu, KR Harsha, J Singh, N Shree… - BMC Pharmacology and …, 2014 - Springer
Background 11ß–hydroxysteroid dehydrogenase type1 (11β-HSD1) converts inactive
glucocorticoids to active glucocorticoids which, in excess, leads to development of the various risk …

CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese …

TM Anil, C Harish, MN Lakshmi, KR Harsha… - Cardiovascular …, 2014 - Springer
Objectives AMP activated protein kinase (AMPK) regulates the coordination of anabolic and
catabolic processes and is an attractive therapeutic target for T2DM, obesity and metabolic …

Semi-supervised pipeline for autonomous annotation of SARS-CoV-2 genomes

…, A Agarwal, G Nayar, S Bianco, H Krishnareddy… - Viruses, 2021 - mdpi.com
SARS-CoV-2 genomic sequencing efforts have scaled dramatically to address the current
global pandemic and aid public health. However, autonomous genome annotation of SARS-…

[PDF][PDF] Semi-supervised identification of SARS-CoV-2

CC-BY 4.0 International license available under a was not certified by peer review) is the
author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made …

Exploiting functional context in biology: Reconsidering classification of bacterial life

…, A Agarwal, K Beck, H Krishnareddy… - 2018 IEEE 34th …, 2018 - ieeexplore.ieee.org
Ontologies are built in various domains such as biology, chemistry, and business. Ontologies
as knowledge bases have great potential to serve as providers of context for analytics not …

Context analytics: Vision, architecture, opportunity

…, E Seabolt, P Schwarz, H Krishnareddy… - 2018 IEEE 34th …, 2018 - ieeexplore.ieee.org
Business actions are often situated in a complex system of people, data and software, and
the pace and quality of decisions often rely on how well knowledge work is coordinated. A …

Semi-supervised identification of sars-cov-2 molecular targets

…, A Agarwal, G Nayar, S Bianco, H Krishnareddy… - bioRxiv, 2021 - biorxiv.org
SARS-CoV-2 genomic sequencing efforts have scaled dramatically to address the current
global pandemic and aid public health. In this work, we analyzed a corpus of 66,000 SARS-…

ICDEW 2018

R Center, I Terrizzano, H Krishnareddy, A Agarwal - ieeexplore.ieee.org
… Eser Kandogan (IBM Almaden Reserach Center), Mary Roth (IBM Almaden Reserach
Center), Ignacio Terrizzano (IBM Almaden Reserach Center), Ed Seabolt (IBM Almaden …