User profiles for Ganesh babu Manoharan
![]() | Ganesh babu ManoharanUniversity of Luxembourg Verified email at uni.lu Cited by 325 |
K-Ras binds calmodulin-related centrin1 with potential implications for K-Ras driven cancer cell stemness
G Manoharan, C Laurini, S Bottone, N Ben Fredj… - Cancers, 2023 - mdpi.com
Simple Summary Trafficking chaperones facilitate the spatio-temporal distribution pattern of
proteins inside cells. In the case of the membrane-anchored protein Ras, trafficking …
proteins inside cells. In the case of the membrane-anchored protein Ras, trafficking …
Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells
GB Manoharan, S Okutachi, D Abankwa - PLoS One, 2022 - journals.plos.org
Phenothiazines (PTZ) were developed as inhibitors of monoamine neurotransmitter receptors,
notably dopamine receptors. Because of this activity they have been used for decades as …
notably dopamine receptors. Because of this activity they have been used for decades as …
Identification of an H-Ras nanocluster disrupting peptide
CL Steffen, G Manoharan, K Pavic… - Communications …, 2024 - nature.com
Hyperactive Ras signalling is found in most cancers. Ras proteins are only active in membrane
nanoclusters, which are therefore potential drug targets. We previously showed that the …
nanoclusters, which are therefore potential drug targets. We previously showed that the …
[HTML][HTML] Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells
Tumorigenesis is a multistep process involving co-operation between several deregulated
oncoproteins. In this study, we unravel previously unrecognized interactions and crosstalk …
oncoproteins. In this study, we unravel previously unrecognized interactions and crosstalk …
Pharmacophore Model for SARS-CoV-2 3CLpro Small-Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors
E Glaab, GB Manoharan… - Journal of Chemical …, 2021 - ACS Publications
Among the biomedical efforts in response to the current coronavirus (COVID-19) pandemic,
pharmacological strategies to reduce viral load in patients with severe forms of the disease …
pharmacological strategies to reduce viral load in patients with severe forms of the disease …
[HTML][HTML] Detection of Ras nanoclustering-dependent homo-FRET using fluorescence anisotropy measurements
G babu Manoharan, C Guzman… - European Journal of …, 2023 - Elsevier
The small GTPase Ras is frequently mutated in cancer and a driver of tumorigenesis. The
recent years have shown great progress in drug-targeting Ras and understanding how it …
recent years have shown great progress in drug-targeting Ras and understanding how it …
A covalent calmodulin inhibitor as a tool to study cellular mechanisms of K-Ras-driven stemness
S Okutachi, GB Manoharan, A Kiriazis… - Frontiers in Cell and …, 2021 - frontiersin.org
Recently, the highly mutated oncoprotein K-Ras4B (hereafter K-Ras) was shown to drive
cancer cell stemness in conjunction with calmodulin (CaM). We previously showed that the …
cancer cell stemness in conjunction with calmodulin (CaM). We previously showed that the …
Retracted: Comparative analysis of distributive linear and nonlinear optimized spectrum sensing clustering techniques in cognitive radio network systems
G Babu R, MS Obaidat, AV, R Manoharan - IET Networks, 2021 - Wiley Online Library
… radio network systems” by authors Ganesh Babu R, Mohammad S. Obaidat, Amudha V,
Rajesh Manoharan and Sitharthan R, IET Netw. 2021;1–11. https://doi.org/10.1049/ntw2.12027 . …
Rajesh Manoharan and Sitharthan R, IET Netw. 2021;1–11. https://doi.org/10.1049/ntw2.12027 . …
PDE6D inhibitors with a new design principle selectively block K-Ras activity
…, P Rosenqvist, M Ora, A Sabt, GB Manoharan… - ACS …, 2019 - ACS Publications
The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a
surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in …
surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in …
High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors
G babu Manoharan, K Kopra, V Eskonen, H Härmä… - Analytical …, 2019 - Elsevier
The KRAS gene is highly mutated in human cancers and the focus of current Ras drug
development efforts. Recently the interface between the C-terminus of K-Ras and calmodulin (…
development efforts. Recently the interface between the C-terminus of K-Ras and calmodulin (…