Simple Summary Trafficking chaperones facilitate the spatio-temporal distribution pattern of
proteins inside cells. In the case of the membrane-anchored protein Ras, trafficking …

Phenothiazines (PTZ) were developed as inhibitors of monoamine neurotransmitter receptors,
notably dopamine receptors. Because of this activity they have been used for decades as …

Hyperactive Ras signalling is found in most cancers. Ras proteins are only active in membrane
nanoclusters, which are therefore potential drug targets. We previously showed that the …

Tumorigenesis is a multistep process involving co-operation between several deregulated
oncoproteins. In this study, we unravel previously unrecognized interactions and crosstalk …

Among the biomedical efforts in response to the current coronavirus (COVID-19) pandemic,
pharmacological strategies to reduce viral load in patients with severe forms of the disease …

The small GTPase Ras is frequently mutated in cancer and a driver of tumorigenesis. The
recent years have shown great progress in drug-targeting Ras and understanding how it …

Recently, the highly mutated oncoprotein K-Ras4B (hereafter K-Ras) was shown to drive
cancer cell stemness in conjunction with calmodulin (CaM). We previously showed that the …

… radio network systems” by authors Ganesh Babu R, Mohammad S. Obaidat, Amudha V,
Rajesh Manoharan and Sitharthan R, IET Netw. 2021;1–11. https://doi.org/10.1049/ntw2.12027 . …

The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a
surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in …

The KRAS gene is highly mutated in human cancers and the focus of current Ras drug
development efforts. Recently the interface between the C-terminus of K-Ras and calmodulin (…