Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

BACKGROUND: We investigated the use of deep brain stimulation (DBS) of the ventral
capsule/ventral striatum (VC/VS) for treatment refractory depression. METHODS: Fifteen patients …

Deep brain stimulation (DBS) has emerged as a safe, effective, and reversible treatment for
a number of movement disorders. This has prompted investigation of its use for other …

The ability to optimize behavioural performance when confronted with continuously evolving
environmental demands is a key element of human cognition. The dorsal anterior cingulate …

Epileptic seizures are traditionally characterized as the ultimate expression of monolithic,
hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we …

Background Multiple open-label trials of deep brain stimulation (DBS) for treatment-resistant
depression (TRD), including those targeting the ventral capsule/ventral striatum target, have …

We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in
two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. …

The human dorsal anterior cingulate cortex (dACC) has been implicated in cognitive processes
that have been proposed to play a role in integrating contextual information needed to …

Available treatment options for TN have different risks and benefits stemming from their
differing success rates and complication profiles (Table 1). A careful consideration of these …

Background Gene transfer of glutamic acid decarboxylase (GAD) and other methods that
modulate production of GABA in the subthalamic nucleus improve basal ganglia function in …