Mechanisms of deep brain stimulation
…, JJ Cheng, EN Eskandar - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression
…, AR Rezai, LL Carpenter, GM Friehs, EN Eskandar… - Biological …, 2009 - Elsevier
BACKGROUND: We investigated the use of deep brain stimulation (DBS) of the ventral
capsule/ventral striatum (VC/VS) for treatment refractory depression. METHODS: Fifteen patients …
capsule/ventral striatum (VC/VS) for treatment refractory depression. METHODS: Fifteen patients …
Mechanisms of deep brain stimulation for obsessive compulsive disorder: effects upon cells and circuits
…, CA Eckhardt, SA Sheth, EN Eskandar - Frontiers in integrative …, 2012 - frontiersin.org
Deep brain stimulation (DBS) has emerged as a safe, effective, and reversible treatment for
a number of movement disorders. This has prompted investigation of its use for other …
a number of movement disorders. This has prompted investigation of its use for other …
Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation
…, ZM Williams, DD Dougherty, G Bush, EN Eskandar - Nature, 2012 - nature.com
The ability to optimize behavioural performance when confronted with continuously evolving
environmental demands is a key element of human cognition. The dorsal anterior cingulate …
environmental demands is a key element of human cognition. The dorsal anterior cingulate …
Single-neuron dynamics in human focal epilepsy
…, JA Donoghue, LR Hochberg, EN Eskandar… - Nature …, 2011 - nature.com
Epileptic seizures are traditionally characterized as the ultimate expression of monolithic,
hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we …
hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we …
A randomized sham-controlled trial of deep brain stimulation of the ventral capsule/ventral striatum for chronic treatment-resistant depression
…, MT Bhati, JP O'Reardon, EN Eskandar… - Biological …, 2015 - Elsevier
Background Multiple open-label trials of deep brain stimulation (DBS) for treatment-resistant
depression (TRD), including those targeting the ventral capsule/ventral striatum target, have …
depression (TRD), including those targeting the ventral capsule/ventral striatum target, have …
Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease
AD Lam, G Deck, A Goldman, EN Eskandar… - Nature medicine, 2017 - nature.com
We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in
two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. …
two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. …
Human anterior cingulate neurons and the integration of monetary reward with motor responses
…, G Bush, SL Rauch, GR Cosgrove, EN Eskandar - Nature …, 2004 - nature.com
The human dorsal anterior cingulate cortex (dACC) has been implicated in cognitive processes
that have been proposed to play a role in integrating contextual information needed to …
that have been proposed to play a role in integrating contextual information needed to …
Surgical treatment of trigeminal neuralgia
SKB Bick, EN Eskandar - Neurosurgery Clinics, 2017 - neurosurgery.theclinics.com
Available treatment options for TN have different risks and benefits stemming from their
differing success rates and complication profiles (Table 1). A careful consideration of these …
differing success rates and complication profiles (Table 1). A careful consideration of these …
AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial
…, SG Ojemann, AW Flaherty, EN Eskandar… - The Lancet …, 2011 - thelancet.com
Background Gene transfer of glutamic acid decarboxylase (GAD) and other methods that
modulate production of GABA in the subthalamic nucleus improve basal ganglia function in …
modulate production of GABA in the subthalamic nucleus improve basal ganglia function in …