[HTML][HTML] Sepsis—pathophysiology and therapeutic concepts
D Jarczak, S Kluge, A Nierhaus - Frontiers in medicine, 2021 - frontiersin.org
Sepsis is a life-threatening condition and a global disease burden. Today, the heterogeneous
syndrome is defined as severe organ dysfunction caused by a dysregulated host response …
syndrome is defined as severe organ dysfunction caused by a dysregulated host response …
Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany
K Roedl, D Jarczak, L Thasler, M Bachmann… - Australian Critical …, 2021 - Elsevier
Background There are large uncertainties with regard to the outcome of patients with
coronavirus disease 2019 (COVID-19) and mechanical ventilation (MV). High mortality (50–97%) …
coronavirus disease 2019 (COVID-19) and mechanical ventilation (MV). High mortality (50–97%) …
Cytokine storm—definition, causes, and implications
D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
The human innate and adaptive immune systems consist of effector cells producing cytokines
(interleukins, interferons, chemokines, and numerous other mediators). Usually, a fragile …
(interleukins, interferons, chemokines, and numerous other mediators). Usually, a fragile …
Clonal expansion and activation of tissue-resident memory-like TH17 cells expressing GM-CSF in the lungs of patients with severe COVID-19
…, E Rosati, P Bacher, D Kylies, D Jarczak… - Science …, 2021 - science.org
Hyperinflammation contributes to lung injury and subsequent acute respiratory distress
syndrome with high mortality in patients with severe coronavirus disease 2019 (COVID-19). To …
syndrome with high mortality in patients with severe coronavirus disease 2019 (COVID-19). To …
Hemoadsorption by CytoSorb in septic patients: a case series
K Kogelmann, D Jarczak, M Scheller, M Drüner - Critical Care, 2017 - Springer
Background Septic shock, defined as life-threatening organ dysfunction caused by a
dysregulated host response to infection, is a highly lethal condition that causes substantial …
dysregulated host response to infection, is a highly lethal condition that causes substantial …
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized …
…, G Michels, S Kluge, A Nierhaus, D Jarczak… - Intensive Care …, 2022 - Springer
Purpose Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We
evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves …
evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves …
Effect of regional citrate anticoagulation vs systemic heparin anticoagulation during continuous kidney replacement therapy on dialysis filter life span and mortality …
…, C Putensen, JC Schewe, S Kluge, D Jarczak… - Jama, 2020 - jamanetwork.com
Importance Although current guidelines suggest the use of regional citrate anticoagulation (which
involves the addition of a citrate solution to the blood before the filter of the …
involves the addition of a citrate solution to the blood before the filter of the …
[HTML][HTML] Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection
…, M Lütgehetmann, MM Addo, D Jarczak… - Cell Reports …, 2022 - cell.com
We here investigate the impact of antiviral treatments such as remdesivir on intra-host genomic
diversity and emergence of SARS-CoV2 variants in patients with a prolonged course of …
diversity and emergence of SARS-CoV2 variants in patients with a prolonged course of …
The majority of male patients with COVID-19 present low testosterone levels on admission to Intensive Care in Hamburg, Germany: a retrospective cohort study
M Schroeder, B Tuku, D Jarczak, A Nierhaus, T Bai… - MedRxiv, 2020 - medrxiv.org
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to
spread worldwide and pose a major public health burden. There is increasing evidence that …
spread worldwide and pose a major public health burden. There is increasing evidence that …
High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study
…, Z Mueller, A Parplys, D Jarczak… - Emerging microbes & …, 2021 - Taylor & Francis
Male sex was repeatedly identified as a risk factor for death and intensive care admission.
However, it is yet unclear whether sex hormones are associated with disease severity in …
However, it is yet unclear whether sex hormones are associated with disease severity in …