User profiles for Deyou Zheng
![]() | Deyou Zheng, Ph.D.Albert Einstein College of Medicine Verified email at einsteinmed.org Cited by 24063 |
Distinct factors control histone variant H3. 3 localization at specific genomic regions
The incorporation of histone H3 variants has been implicated in the epigenetic memory of
cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3.3, we …
cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3.3, we …
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …
[HTML][HTML] Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade
The treatment of advanced prostate cancer has been transformed by novel antiandrogen
therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) …
therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) …
What is a gene, post-ENCODE? History and updated definition
While sequencing of the human genome surprised us with how many protein-coding genes
there are, it did not fundamentally change our perspective on what a gene is. In contrast, the …
there are, it did not fundamentally change our perspective on what a gene is. In contrast, the …
Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice
…, DS Oristian, L Polak, M Kadaja, A Asare, D Zheng… - Nature, 2015 - nature.com
Adult stem cells occur in niches that balance self-renewal with lineage selection and
progression during tissue homeostasis. Following injury, culture or transplantation, stem cells …
progression during tissue homeostasis. Following injury, culture or transplantation, stem cells …
Pseudogenes in the ENCODE regions: consensus annotation, analysis of transcription, and evolution
Arising from either retrotransposition or genomic duplication of functional genes, pseudogenes
are “genomic fossils” valuable for exploring the dynamics and evolution of genes and …
are “genomic fossils” valuable for exploring the dynamics and evolution of genes and …
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive
soft-tissue sarcomas that may occur sporadically, in association with neurofibromatosis type …
soft-tissue sarcomas that may occur sporadically, in association with neurofibromatosis type …
Androgen receptor signaling regulates DNA repair in prostate cancers
We demonstrate that the androgen receptor (AR) regulates a transcriptional program of
DNA repair genes that promotes prostate cancer radioresistance, providing a potential …
DNA repair genes that promotes prostate cancer radioresistance, providing a potential …
Phase separation drives aberrant chromatin looping and cancer development
…, SD Byrum, L Cai, AJ Tackett, D Zheng… - Nature, 2021 - nature.com
The development of cancer is intimately associated with genetic abnormalities that target
proteins with intrinsically disordered regions (IDRs). In human haematological malignancies, …
proteins with intrinsically disordered regions (IDRs). In human haematological malignancies, …
ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss
…, I Sirota, BS Carver, J Wongvipat, HI Scher, D Zheng… - Nature medicine, 2013 - nature.com
Studies of ETS-mediated prostate oncogenesis have been hampered by a lack of suitable
experimental systems. Here we describe a new conditional mouse model that shows robust, …
experimental systems. Here we describe a new conditional mouse model that shows robust, …