The incorporation of histone H3 variants has been implicated in the epigenetic memory of
cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3.3, we …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

The treatment of advanced prostate cancer has been transformed by novel antiandrogen
therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) …

While sequencing of the human genome surprised us with how many protein-coding genes
there are, it did not fundamentally change our perspective on what a gene is. In contrast, the …

Adult stem cells occur in niches that balance self-renewal with lineage selection and
progression during tissue homeostasis. Following injury, culture or transplantation, stem cells …

Arising from either retrotransposition or genomic duplication of functional genes, pseudogenes
are “genomic fossils” valuable for exploring the dynamics and evolution of genes and …

Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive
soft-tissue sarcomas that may occur sporadically, in association with neurofibromatosis type …

We demonstrate that the androgen receptor (AR) regulates a transcriptional program of
DNA repair genes that promotes prostate cancer radioresistance, providing a potential …

The development of cancer is intimately associated with genetic abnormalities that target
proteins with intrinsically disordered regions (IDRs). In human haematological malignancies, …

Studies of ETS-mediated prostate oncogenesis have been hampered by a lack of suitable
experimental systems. Here we describe a new conditional mouse model that shows robust, …